ERAP1 allotype combinations from CD8/TILlow tumors have reduced trimming activity. ERAP1 allotype combinations from CD8/TILlow tumors have reduced trimming.

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ERAP1 allotype combinations from CD8/TILlow tumors have reduced trimming activity. ERAP1 allotype combinations from CD8/TILlow tumors have reduced trimming activity. A, The total trimming activity for all 20 X-SHL8 substrates for each allotype combination were combined and grouped into CD8/TIL status. Overall trimming for each CD8/TIL group is represented as AUC. B, Table showing both the individual AUC for allotype pairs in each CD8/TIL group and the mean for each group. C, Specificity of ERAP1 trimming activity from those found exclusively in CD8/TILhigh, CD8/TILmoderate, or CD8/TILlow tumors towards X-SHL8 amino acids grouped based on physicochemical properties; basic, acidic, polar uncharged, aliphatic, aromatic, and special. Data from A–C, pooled from 4 independent experimental repeats ± SEM (***, P ≤ 0.001; **, P ≤ 0.01; *, P ≤ 0.05). Emma Reeves et al. Cancer Immunol Res 2019;7:1202-1213 ©2019 by American Association for Cancer Research