Immune pathomechanism of drug hypersensitivity reactions

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Presentation transcript:

Immune pathomechanism of drug hypersensitivity reactions Werner J. Pichler, MD, Dean J. Naisbitt, PhD, B. Kevin Park, PhD Journal of Allergy and Clinical Immunology Volume 127, Issue 3, Pages S74-S81 (March 2011) DOI: 10.1016/j.jaci.2010.11.048 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Systems involved in drug hypersensitivity. Journal of Allergy and Clinical Immunology 2011 127, S74-S81DOI: (10.1016/j.jaci.2010.11.048) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Drug and patient factors involved in the development of drug hypersensitivity. The main areas, stimulation of dendritic cells and their drug-induced maturation, formation of antigenic sites, preferential presentation of drugs/haptens by certain HLA alleles and reaction of a hapten-peptide complex or of the drug directly with certain TCRs, participation of Treg cells, and mechanisms of cytotoxicity, were presented at the 4th Drug Hypersensitivity Meeting and are discussed in the text. Journal of Allergy and Clinical Immunology 2011 127, S74-S81DOI: (10.1016/j.jaci.2010.11.048) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions