Severe asthma: Lessons from the Severe Asthma Research Program

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Presentation transcript:

Severe asthma: Lessons from the Severe Asthma Research Program Sally E. Wenzel, MD, William W. Busse, MD Journal of Allergy and Clinical Immunology Volume 119, Issue 1, Pages 14-21 (January 2007) DOI: 10.1016/j.jaci.2006.10.025 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Kaplan-Meier survival curves for onset of exacerbations in children with mild compared with severe asthma followed prospectively. FVC, Forced vital capacity. Reprinted with permission from Fitzpatrick AM, Gaston B, Erzurum S, Teague W. Features of severe asthma in school age children: atopy and increased exhaled nitric oxide. J Allergy Clin Immunol 2006;118:1218-25.26 Journal of Allergy and Clinical Immunology 2007 119, 14-21DOI: (10.1016/j.jaci.2006.10.025) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Mechanistic studies explored through the SARP network. Journal of Allergy and Clinical Immunology 2007 119, 14-21DOI: (10.1016/j.jaci.2006.10.025) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Individual HDAC activities in PBMCs from normal individuals, patients with nonsevere asthma (with and without inhaled corticosteroids [ICSs]), and patients with severe asthma. Patients with severe asthma have lower levels of HDAC activity. ∗P < .05; ∗∗P < .01; NS, Not significant. Reprinted with permission from Kotaru C, Schoonover KJ, Trudeau JB, Huynh ML, Zhou X, Hu H, et al. Regional fibroblast heterogeneity in the lung: implications for remodeling. Am J Respir Crit Care Med 2006;173:1208-15.29 Journal of Allergy and Clinical Immunology 2007 119, 14-21DOI: (10.1016/j.jaci.2006.10.025) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions