Fig. 3. The role of DCs and DC-SIGN in HDM allergy

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Fig. 3. The role of DCs and DC-SIGN in HDM allergy Fig. 3. The role of DCs and DC-SIGN in HDM allergy. Decreased expression of DC-SIGN and more immature phenotypes in MDDCs from Der p-sensitive asthmatic patients may partially explain the enhancement of the Th2 response associated with HDM-related allergies. In addition, Der p can modulate differentiation and maturation of monocyte-derived DCs through DC-SIGN binding and downregulation of its expression, which may result in an aletred polarization activity, leading to the Th2 cytokine immune response. Fig. 3. The role of DCs and DC-SIGN in HDM allergy. Decreased expression of DC-SIGN and more immature phenotypes in MDDCs from Der p-sensitive asthmatic patients may partially explain the enhancement of the Th2 response associated with HDM-related allergies. In addition, Der p can modulate differentiation and maturation of monocyte-derived DCs through . . . Allergy Asthma Immunol Res. 2013 Mar;5(2):68-74. http://dx.doi.org/10.4168/aair.2013.5.2.68