Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis Gabriela F Meresman, Ph.D., Susana Vighi, M.D., Ricardo.

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Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis Gabriela F Meresman, Ph.D., Susana Vighi, M.D., Ricardo A Buquet, M.D., Ph.D., Oscar Contreras-Ortiz, M.D., Marta Tesone, Ph.D., Lı́a S Rumi, M.D. Fertility and Sterility Volume 74, Issue 4, Pages 760-766 (October 2000) DOI: 10.1016/S0015-0282(00)01522-3

Figure 1 Representative photomicrograph of histologic section from eutopic endometrium from woman without endometriosis showing immunostaining of endometrial sections for apoptosis by the TUNEL technique. Note the presence of numerous immunostained apoptotic cells. Original magnification was ×400. Meresman. Apoptosis, Bcl-2, and Bax in eutopic endometrium. Fertil Steril 2000. Fertility and Sterility 2000 74, 760-766DOI: (10.1016/S0015-0282(00)01522-3)

Figure 2 Spontaneous apoptosis in eutopic endometria from patients with endometriosis (EDT) and control women (CONTROL). Histologic sections were immunostained by the TUNEL technique (see text). The numbers of apoptotic cells were determined by counting labeled cells in ×630 magnification randomly selected fields. Data were expressed as the apoptotic cell mean/field. □ = control; ■ EDT. ∗P<.001. Meresman. Apoptosis, Bcl-2, and Bax in eutopic endometrium. Fertil Steril 2000. Fertility and Sterility 2000 74, 760-766DOI: (10.1016/S0015-0282(00)01522-3)

Figure 3 Spontaneous apoptosis in eutopic endometria from patients with endometriosis (EDT) and control women (CONTROL), in the late proliferative phase (LP) and late secretory phase (LS) of the menstrual cycle. Histologic sections were immunostained by the TUNEL technique (see text). The numbers of apoptotic cells were determined by counting labeled cells in ×630 magnification randomly selected fields. Data were expressed as the apoptotic cell mean/field. ∗LP: Control vs. endometriosis P<.05. ∗∗LS: Control vs, endometriosis P<.001. Meresman. Apoptosis, Bcl-2, and Bax in eutopic endometrium. Fertil Steril 2000. Fertility and Sterility 2000 74, 760-766DOI: (10.1016/S0015-0282(00)01522-3)

Figure 4 Sections immunostained for Bcl-2 and Bax protein expression. (A), Bcl-2 protein expression in proliferative endometrium from a patient with endometriosis (×200). (B), Bax protein expression in secretory endometrium from a control subject (×400). Note strong immunopositivity in endometrial sections. Bcl-2 and Bax staining predominated in glandular cells. Meresman. Apoptosis, Bcl-2, and Bax in eutopic endometrium. Fertil Steril 2000. Fertility and Sterility 2000 74, 760-766DOI: (10.1016/S0015-0282(00)01522-3)