Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin- induced asthma Yukio Kawagishi, MDa,b, Haruhisa Mita, PhDb, Masami Taniguchi,

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Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin- induced asthma Yukio Kawagishi, MDa,b, Haruhisa Mita, PhDb, Masami Taniguchi, MDb, Muneharu Maruyama, MDa, Rokuo Oosaki, MDa, Noritaka Higashi, MDb, Tatsuhiko Kashii, MDa, Masashi Kobayashi, MDa, Kazuo Akiyama, MDb Journal of Allergy and Clinical Immunology Volume 109, Issue 6, Pages 936-942 (June 2002) DOI: 10.1067/mai.2002.124466 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 Basal levels of urinary LTE4 in each group. Horizontal bars indicate geometric means. Patients with wild-type and variant-type alleles are expressed as open and filled circles , respectively. *P < .001 compared with the control group; **P < .0001 compared with the control group; †P < .0001 compared with the ATA group. Journal of Allergy and Clinical Immunology 2002 109, 936-942DOI: (10.1067/mai.2002.124466) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 2 Ratio of increase in urinary LTE4 after aspirin challenge. The data are presented as means ± SEM of the percent increase over the prechallenge basal levels. Patients with wild-type and variant-type alleles are expressed as open and filled bars , respectively. *P < .05 compared with wild-type patients at 6 hours after aspirin challenge. Journal of Allergy and Clinical Immunology 2002 109, 936-942DOI: (10.1067/mai.2002.124466) Copyright © 2002 Mosby, Inc. Terms and Conditions