This month in Gastroenterology Laura Harrell, Eugene B. Chang  Gastroenterology  Volume 128, Issue 4, Pages 811-813 (April 2005) DOI: 10.1053/j.gastro.2005.02.043 Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 1 Percentage of patients achieving response. Response was defined as a decrease in UCDAI of ≥4 at week 12. Values for the intention-to-treat analysis are based on the entire 54 patients enrolled, while those for the per-protocol analysis are based on 52. One patient withdrew from each of the placebo- and ova-treatment groups. Gastroenterology 2005 128, 811-813DOI: (10.1053/j.gastro.2005.02.043) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 2 (A) Proportion of patients hospitalized, by treatment group. (B) Cumulative number of surgeries and procedures over time for patients randomized as responders. All patients received infliximab 5 mg/kg at weeks 0, 2, and 6. Assessments of fistula response were made at weeks 10 and 14. Patients were randomized at week 14 and assigned to maintenance infusions of placebo or infliximab 5 mg/kg every 8 weeks through week 46. The figure provides the total number of surgeries and procedures by time in each treatment group. Gastroenterology 2005 128, 811-813DOI: (10.1053/j.gastro.2005.02.043) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 3 Summary of results of the CURE Prophylactic Trial. “Bleeding” is development of first esophageal variceal hemorrhage. “Failure” is treatment failure as defined by a severe adverse event requiring discontinuation of therapy or development of first variceal hemorrhage. “OLT” is orthotopic liver transplantation during the follow-up period. “Direct cost” are total, cumulative, mean, direct costs in US dollars. Gastroenterology 2005 128, 811-813DOI: (10.1053/j.gastro.2005.02.043) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 4 Kinetics and disease localization in IL-10−/− (A) E faecalis– and (B) E coli– monoassociated mice. Gastroenterology 2005 128, 811-813DOI: (10.1053/j.gastro.2005.02.043) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 5 Real time analysis of actin dynamics during purse-string wound closure in Caco-2 cells. Closure of oligocellular epithelial wounds was analyzed in Caco-2 cells stably expressing EGFP-β-actin. Within 2 minutes after wounding, actin polymerization occurred at the wound edge (arrow). Residual EGFP fluorescence of dead cells retained within the wound is apparent at time points up to 8 minutes (note top of wound). By 8 minutes, a continuous ring of actin (arrow) was present and the wound rounded, indicating the development of circumferential tension. This was followed by contraction of the actomyosin ring as the wound closed. Most activity occurred with the first 32 minutes and wound closure was complete by 56 minutes (arrow). The wound healing process was associated with stretching and flattening of some cells, resulting in a gradual shift of some areas out of the plane of focus. Bar = 20 μm. Gastroenterology 2005 128, 811-813DOI: (10.1053/j.gastro.2005.02.043) Copyright © 2005 American Gastroenterological Association Terms and Conditions