Hypercholesterolemia impairs endothelium-dependent relaxations to aggregating platelets in porcine iliac arteries Kimihiro Komori, MD, Hiroaki Shimokawa,

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Presentation transcript:

Hypercholesterolemia impairs endothelium-dependent relaxations to aggregating platelets in porcine iliac arteries Kimihiro Komori, MD, Hiroaki Shimokawa, MD, Paul M. Vanhoutte, MD, PhD Journal of Vascular Surgery Volume 10, Issue 3, Pages 318-325 (September 1989) DOI: 10.1016/0741-5214(89)90448-5 Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

Fig. 1 Tension recordings in isolated iliac arteries from a control (left) and a cholesterol-fed pig (right). Platelets were added to the organ chamber during a contraction evoked by prostaglandin F2α (2 × 10−6 mol/L) in the presence of indomethacin (10−5 mol/L) and ketanserin (10−6 mol/L). W0, Washout. Journal of Vascular Surgery 1989 10, 318-325DOI: (10.1016/0741-5214(89)90448-5) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

Fig. 2 Left, Effects of methiothepin and apyrase on platelet-induced relaxations in iliac artery rings with endothelium from control pigs. Right, Endothelium-dependent relaxations to aggregating platelets in iliac arteries from control and cholesterol-fed pigs. The relaxations were examined during a contraction evoked by prostaglandin F2α (2 × 10−6 mol/L) in the presence of indomethacin (10−5 mol/L) and ketanserin (10−6 mol/L). The asterisk denotes a significant difference (p < 0.05) between the control and cholesterol-fed pigs. Journal of Vascular Surgery 1989 10, 318-325DOI: (10.1016/0741-5214(89)90448-5) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

Fig. 3 Cumulative concentration-response curves to ADP in iliac arteries from control and cholesterol-fed pigs during a contraction evoked by prostaglandin F2α (2 × 10−6 mol/L) in the presence of indomethacin (10−5 mol/L). The effects of apyrase on ADP-induced relaxation in control vessels with the endothelium are also shown. The asterisk denotes a significant difference (p < 0.05) between the control and cholesterol-fed pigs. Journal of Vascular Surgery 1989 10, 318-325DOI: (10.1016/0741-5214(89)90448-5) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

Fig. 4 Cumulative concentration-response curves to serotonin in iliac arteries from control and cholesterol-fed pigs during a contraction evoked by prostaglandin F2α (2 × 10−6 mol/L), in the presence of ketanserin (10−6 mol/L) and indomethacin (10−5 mol/L). The effects of methiothepin on serotonin-induced relaxations in control arteries with the endothelium are also shown. The asterisk denotes a significant difference (p < 0.05) between the two groups. Journal of Vascular Surgery 1989 10, 318-325DOI: (10.1016/0741-5214(89)90448-5) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

Fig. 5 Effects of aggregating platelets (75,000/μl) in quiescent rings of iliac arteries from control and cholesterol-fed pigs, in the presence of indomethacin (10−5 mol/L). Effects of dazoxiben (10−5 mol/L), ketanserin (10−5 mol/L), and methiothepin (10−6 mol/L) on the platelet-induced contractions in rings without endothelium are also shown. The asterisk denotes a statistically significant difference between rings with and without endothelium, and the dagger shows a significant difference (p < 0.05) between arteries from control and cholesterol-fed pigs. Journal of Vascular Surgery 1989 10, 318-325DOI: (10.1016/0741-5214(89)90448-5) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

Fig. 6 Cumulative concentration-response curves to serotonin in quiescent rings of iliac arteries from control and cholesterol-fed pigs in the presence of indomethacin (10−5 mol/L). Effects of ketanserin (10−6 mol/L) on serotonin-induced contractions of rings without endothelium are also shown. The ED30 for serotonin-induced contractions in rings without endothelium averaged 6.6 ± 0.2 − log mol/L and 6.5 ± 0.2 − log mol/L (n = 6) in rings of control and cholesterol-fed pigs, respectively (not significantly different). The asterisk denotes a statistically significant difference (p < 0.05) between rings with and without endothelium, and the dagger shows a significant difference (p < 0.05) between arteries from control and cholesterol-fed pigs. Journal of Vascular Surgery 1989 10, 318-325DOI: (10.1016/0741-5214(89)90448-5) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions