Tissue distribution of MMP-9 and MMP-2 in adult rat brain.

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Tissue distribution of MMP-9 and MMP-2 in adult rat brain. Tissue distribution of MMP-9 and MMP-2 in adult rat brain. Sections of dorsal hippocampus demonstrating the distribution of MMP-9 and MMP-2 mRNA and protein are shown.A, Nissl staining of a hippocampal coronal section.mol. layer, Molecular layer; lacun. mol., lacunosum molecular layer; rad., radiatum layer. Scale bar, 1 mm. B, Tissue distribution of MMP-9 mRNA (in situ hybridization; left image) and protein (immunohistochemistry; right image). MMP-9 mRNA is enriched in neuronal fields of the hippocampus. The right image shows enrichment of MMP-9 protein in neuronal bodies of the dentate gyrus and the CA subfields. Diffuse MMP-9 protein staining, especially in the lacunosum molecular layer, can also be discerned.C, Tissue distribution of MMP-2 mRNA (left image) and protein (right image). In contrast to MMP-9, MMP-2 mRNA and protein are diffusely distributed over the entire hippocampus. Arek Szklarczyk et al. J. Neurosci. 2002;22:920-930 ©2002 by Society for Neuroscience