Fig. 5 Treatment with BMS-986165 (PO BID) protects from wasting and colitis in two SCID mouse models. Treatment with BMS-986165 (PO BID) protects from.

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Fig. 5 Treatment with BMS-986165 (PO BID) protects from wasting and colitis in two SCID mouse models. Treatment with BMS-986165 (PO BID) protects from wasting and colitis in two SCID mouse models. A blocking anti-p40 antibody was included as a comparator. In the anti-CD40 antibody–induced colitis model (n = 5 mice per group), BMS-986165 treatment was initiated immediately before challenge with anti-CD40 antibody, and (A) the mean body weight was assessed throughout the course of the disease (*P < 0.05 and **P < 0.01, one-way ANOVA with Dunnett’s posttest). (B) Histological evaluation of colons at the end of the study was scored (20× magnification), P values from one-way ANOVA with Dunnett’s posttest. (C) Representative images of hematoxylin and eosin (H&E)–stained colon sections from mice treated with vehicle, BMS-986165 (15 and 50 mg/kg), and anti-p40 antibody in the anti-CD40 antibody–induced colitis model after 6 days. (D) PK of BMS-986165 in study mice collected on the last day of the anti-CD40 antibody–induced model with the data represented as time after the morning dose. In the CD4+CD45RBhigh transfer colitis model (n = 9 mice per group), treatment with BMS-986165 was initiated immediately after transfer of cells, and (E) the mean body weight was assessed throughout the course of the disease (*P < 0.05 and **P < 0.01, one-way ANOVA with Dunnett’s posttest). (F) Histological evaluation of colons at the end of the study was scored. P values were calculated from unpaired nonparametric one-sided Mann-Whitney test. (G) Representative images of H&E-stained colon sections at day 48 from mice treated with vehicle, BMS-986165 (10 mg/kg), and anti-p40 antibody in the CD4+CD45RBhigh transfer colitis model (10× magnification). (H) PK of BMS-986165 in study mice collected on the last day of the CD4+CD45RBhigh transfer model with the data represented as time after the morning dose. The results represent means ± SEM. James R. Burke et al., Sci Transl Med 2019;11:eaaw1736 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works