Real-time quaking-induced conversion reactions seeded with cerebrospinal fluid from a patient with sporadic Creutzfeldt-Jakob disease (sCJD) (red) and.

Slides:



Advertisements
Similar presentations
Catch the Wave Wave Rate D = measured distance between sensors.
Advertisements

Disease-Associated Prion Protein in Vessel Walls
(A) Diffusion-tensor imaging assessment of white matter damage after traumatic brain injury (TBI). (A) Diffusion-tensor imaging assessment of white matter.
Various lower limb ankle orthoses used in the management of distal lower limb muscle weakness in patients with inherited neuropathies. Various lower limb.
Nat. Rev. Neurol. doi: /nrneurol
Nat. Rev. Neurol. doi: /nrneurol
Plain CT scan of head (a) and prethrombectomy (b, c), during thrombectomy (d, e, f) and post-thrombectomy (g, h) digital subtraction angiogram images in.
Plain CT scan of head (a) and prethrombectomy (b) and post-thrombectomy (c, e, f) digital subtraction angiograms in a 58-year-old man with a short history.
Fig. 2. RT-QuIC testing of sCJD and vCJD brain and skin samples.
 These traces show typical electrophysiological features of a pre-synaptic neuromuscular transmission disorder in a patient with LEMS. The traces on the.
(A) Confocal image of a skin biopsy taken from the finger of a healthy subject illustrating different subtypes of sensory fibre: PGP 9.5 is used as an.
Typical MRI features of Creutzfeldt-Jakob disease (CJD).
The MR scan of brain of our case vignette patient showing significant occipital lobe atrophy (especially left sided) with parietal lobe involvement as.
Variant or sporadic Creutzfeldt-Jakob disease?
Volume 377, Issue 9764, Pages (February 2011)
(A) Confocal image of a skin biopsy taken from the finger of a healthy subject illustrating different subtypes of sensory fibre: PGP 9.5 is used as an.
Typical imaging findings.
Multifocal motor neuropathy with conduction block.
‘Poppers’ retinopathy.
Photograph of the legs of a patient with inherited erythromelalgia, showing erythema to the level of the mid-calf. Photograph of the legs of a patient.
MRI scans show coronal sections of the brain and right hippocampus at baseline, 9 months, 2 years (when he was diagnosed with mild cognitive impairment)
Flexion cervical spine MRI in Hirayama disease showing expansion of the dural venous plexus with presumed chronic ischaemic damage preferentially involving.
Schematic representation of hepatitis E virus (HEV) genotype 3 in developed countries. Schematic representation of hepatitis E virus (HEV) genotype 3 in.
Fundus photographs showing pale discs and retinal vessel attenuation.
MR scan of brain in four patients presenting as mimics of prion disease. MR scan of brain in four patients presenting as mimics of prion disease. (A) C9orf72.
Case 2—Urgent CSF divergence surgery restored visual function.
Confocal images of skin biopsies taken from the legs of a control subject (A) and a patient with small fibre neuropathy secondary to HIV (B) showing PGP.
Susceptibility-weighted MRI of ex vivo hippocampal tissue.
This patient (shown from behind) presented with slowly progressive weakness and wasting of the shoulder girdles, neurophysiological evidence of denervation.
Goldmann visual fields of a patient with ‘stacked isopters’.
Photograph of the legs of a patient with inherited erythromelalgia, showing erythema to the level of the mid-calf. Photograph of the legs of a patient.
Indocyanine green angiography (ICG) and fluorescein angiography (FA) of the right eye (case 8). Indocyanine green angiography (ICG) and fluorescein angiography.
Confocal images of skin biopsies taken from the legs of a control subject (A) and a patient with small fibre neuropathy secondary to HIV (B) showing PGP.
Injection sites for greater occipital nerve (GON) block.
(A) Showing 10 untreated Parkinson patients; all positive for α-synuclein and 3-nitro-tyrosin (a marker for mitochondrial stress) on sigmoidoscopy and.
Page 1 of a fact sheet available at www. neurosymptoms. org
Goldmann machine. Goldmann machine. The patient's eye is positioned at the centre of a white hemispheric bowl, with the examiner looking through an eyepiece.
Humphrey perimetry (SITA-Standard 24–2): (A) 1 month postquinine overdose, showing marked constriction of the visual field; (B) 6 months postquinine overdose,
Suggested algorithm for genetic testing in Charcot–Marie–Tooth disease (CMT) and related disorders in the age of disease-specific gene panels. *Motor nerve.
Flexion cervical spine MRI in Hirayama disease showing expansion of the dural venous plexus with presumed chronic ischaemic damage preferentially involving.
Vitamin B12 (cobalamin) is a cofactor in conversion of methylmalonyl coenzyme A (CoA) to succinyl CoA and of homocysteine to methionine. Vitamin B12 (cobalamin)
Autofluorescence left eye (case 3)
(A) Axial CT scan of head at presentation, showing a right occipital hypodense lesion. (A) Axial CT scan of head at presentation, showing a right occipital.
Craniopharyngioma: T1W sagittal MRI shows a large complex suprasellar cystic mass with a fluid level. Craniopharyngioma: T1W sagittal MRI shows a large.
Star cancellation task from the behavioural inattention test
Diagram of a coronal section across the midline of the skull vault, showing a parasagittal mass (hatched) compressing (arrows) the representation of the.
After 4 s of raw magnetoencephalography data (two channels contain obvious artefacts), the door to the magnetically shielded room is opened during recording.
T2 weighted sagittal MRI scans of the cervical spine.
Headache frequency after medication withdrawal in medication-overuse headache. Headache frequency after medication withdrawal in medication-overuse headache.
(A) Frontalis test: unilateral injection of the frontalis muscle with botulinum toxin (BoNT). (A) Frontalis test: unilateral injection of the frontalis.
Suggested algorithm of addressing non-motor symptoms in clinic (modified from Chaudhuri et al).48 HCP, healthcare professional; QoL, quality of life; PDSS,
Sagittal T2-weighted MR scan of spine of case 1 (A) and case 2 (C), showing intramedullary signal hyperintensity at T11/12 in case 2 (C). Sagittal T2-weighted.
Functional tremor. (A) The tremor affects both hands but there is variation in amplitude and frequency between the right and left spirals. Functional tremor. (A)
(A) Pupillary responses by age (from Meisami et al)
The organisation of cortical microcolumns within the sulcal bank, tangentially orientated to the skull, allows their detection with magnetoencephalography.
Papilloedema in a patient with idiopathic intracranial hypertension.
The organisation of cortical microcolumns within the sulcal bank, tangentially orientated to the skull, allows their detection with magnetoencephalography.
Constructive interference in the steady state (CISS) axial (A and B) and gadolinium-enhanced T1W axial (C and D) and coronal (E) MRI show a right-sided.
(A) MR scan of brain from an 82-year-old woman who presented with recurrent episodes of sudden onset needles affecting the face, gum and hand, with facial.
General Medical Council’s (GMC) National Training Survey results for average clinic attendance per week at 33 sites across the UK in General Medical.
Mean profiles over 1 year from the observed Disease Activity Score 28 (DAS28) data for the methotrexate (MTX)-exposed patients after stratifying by predicted.
18F-dopa positron emission tomography (PET) in a normal subject, a patient with idiopathic Parkinson's disease (PD), and a patient with multiple system.
Consensus in diagnosing IIH
Box plot representation of total PDSS (Parkinson’s disease sleep scale) scores obtained by patients with Parkinson’s disease (PD) and controls. Box plot.
Kaplan-Meier table analysis of patients with corticobasal degeneration after onset of symptoms; the y axis refers to proportion of patients who are alive.
Conceptual diagram of dopaminergic system and disease and drug effects
MR scan of brain (coronal sections of fluid attenuation inversion recovery (FLAIR) sequences) in a patient with corticobasal syndrome, showing generalised.
(A) Clinical selection of scapular muscles depending on the side of the elevation of the shoulder in a patient with dystonic head rotation. (A) Clinical.
ROC curve for the TYM-MCI, ACE-R and MMSE in the separation of patients with aMCI/AD from those with SMC. ACE-R, Addenbrooke’s Cognitive Examinations;
Box plot showing the distribution of the TYM-MCI score for patients with SMC and aMCI/AD. aMCI/AD, amnestic mild cognitive impairment or Alzheimer’s disease;
Presentation transcript:

Real-time quaking-induced conversion reactions seeded with cerebrospinal fluid from a patient with sporadic Creutzfeldt-Jakob disease (sCJD) (red) and a patient without sCJD or related prion disorder (blue). Real-time quaking-induced conversion reactions seeded with cerebrospinal fluid from a patient with sporadic Creutzfeldt-Jakob disease (sCJD) (red) and a patient without sCJD or related prion disorder (blue). ThT, thioflavin T. Alison J E Green Pract Neurol 2019;19:49-55 ©2019 by BMJ Publishing Group Ltd