A Metabolic Roadblock in Inflammatory Macrophages

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A Metabolic Roadblock in Inflammatory Macrophages Luke A.J. O’Neill Cell Reports Volume 17, Issue 3, Pages 625-626 (October 2016) DOI: 10.1016/j.celrep.2016.09.085 Copyright © 2016 Terms and Conditions

Figure 1 Metabolic Polarization of Macrophages Treatment of macrophages with LPS + IFNγ leads to NO generation, which impedes the electron transport chain and respiration, driving the pro-inflammatory phenotype of these cells. IL-4 promotes oxidative phosphorylation, which promotes an anti-inflammatory phenotype. The inflammatory M1 macrophage cannot be repolarized to an M2 macrophage by IL-4 unless NO generation is blocked. However, the anti-inflammatory M2 macrophage can be repolarized to an M1 macrophage by LPS + IFNγ. Cell Reports 2016 17, 625-626DOI: (10.1016/j.celrep.2016.09.085) Copyright © 2016 Terms and Conditions