Isolated tumor cells in bone marrow predict reduced survival in node-negative non-small cell lung cancer Bernward Passlick, MD, Boris Kubuschok, MD,

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G.Liguori,G.Pirozzi^, I. Forte, G.Botti, R.Franco, A.La Rocca*, G.Rocco* Istituto Nazionale Tumori Napoli Dip.Anatomia Patologica; Dip.Onc.Sperimentale^;

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Isolated tumor cells in bone marrow predict reduced survival in node-negative non-small cell lung cancer Bernward Passlick, MD, Boris Kubuschok, MD, Jakob R Izbicki, MD, Olaf Thetter, MD, Klaus Pantel, MD The Annals of Thoracic Surgery Volume 68, Issue 6, Pages 2053-2058 (December 1999) DOI: 10.1016/S0003-4975(99)01125-X

Fig 1 Isolated CK18+ cell in the bone marrow of a patient with a resectable NSCLC (adenocarcinoma; pT1, pN0, M0). Alkaline phosphate-anti-alkaline phosphatase (APAAP) staining using monoclonal antibody CK2 against CK18; in order to facilitate the detection of immunocytochemical positive cells, no counter staining was done. The Annals of Thoracic Surgery 1999 68, 2053-2058DOI: (10.1016/S0003-4975(99)01125-X)

Fig 2 Frequency of CK18+ tumor cells in bone marrow of patients with completely resected NSCLC. The Annals of Thoracic Surgery 1999 68, 2053-2058DOI: (10.1016/S0003-4975(99)01125-X)

Fig 3 Overall survival (Kaplan-Meier analysis) in pN0 patients (n = 66) with surgically resected NSCLC depending on the presence (thick line) or absence (thin line) of immunocytochemically CK18+ tumor cells (≥ 2 cells per 4 × 105) in bone marrow. The difference is significant: p = 0.007 by log-rank test. The Annals of Thoracic Surgery 1999 68, 2053-2058DOI: (10.1016/S0003-4975(99)01125-X)