Pradeep Reddy Marri, PhD, Debra A. Stern, MS, Anne L

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Asthma-associated differences in microbial composition of induced sputum Pradeep Reddy Marri, PhD, Debra A. Stern, MS, Anne L. Wright, PhD, Dean Billheimer, PhD, Fernando D. Martinez, MD Journal of Allergy and Clinical Immunology Volume 131, Issue 2, Pages 346-352.e3 (February 2013) DOI: 10.1016/j.jaci.2012.11.013 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Median percentage values of bacterial phyla in samples from asthmatic and nonasthmatic subjects found by using the RDP Classifier, version 2.1. Pie charts show the distribution of organisms for asthmatic and nonasthmatic subjects. Journal of Allergy and Clinical Immunology 2013 131, 346-352.e3DOI: (10.1016/j.jaci.2012.11.013) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Hierarchical clustering of samples from asthmatic and nonasthmatic subjects. The green and blue boxes indicate the asthmatic and nonasthmatic clusters, respectively. A1-A10, Samples from asthmatic patients; C1-C10, samples from nonasthmatic subjects. The numbers on the branches indicate the bootstrap support for the cluster. Journal of Allergy and Clinical Immunology 2013 131, 346-352.e3DOI: (10.1016/j.jaci.2012.11.013) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Relative abundance of 15 bacterial families in samples from asthmatic and nonasthmatic subjects. The value of zero indicates a similar percentage contribution of the bacterial family in both asthmatic and nonasthmatic individuals. A positive value for a bacterial family indicates its higher percentage abundance in asthmatics and a negative value indicates the higher abundance in nonasthmatics. For example, Enterobacteriaceae is ∼4% more abundant in asthmatics. Journal of Allergy and Clinical Immunology 2013 131, 346-352.e3DOI: (10.1016/j.jaci.2012.11.013) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Diversity of samples from asthmatic and nonasthmatic subjects based on bacterial genera. The Shannon Index is a mathematic measure commonly used to characterize the species diversity in a community, and it accounts for both the diversity and evenness of the bacterial species present in samples from asthmatic and nonasthmatic subjects. Journal of Allergy and Clinical Immunology 2013 131, 346-352.e3DOI: (10.1016/j.jaci.2012.11.013) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Rarefaction analysis for samples based on clustering the sequences at 97% identity. Journal of Allergy and Clinical Immunology 2013 131, 346-352.e3DOI: (10.1016/j.jaci.2012.11.013) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Hierarchical clustering of samples from atopic asthmatic and nonasthmatic subjects. A1-A10, Samples from asthmatic patients; C1-C10, samples from nonasthmatic subjects. Journal of Allergy and Clinical Immunology 2013 131, 346-352.e3DOI: (10.1016/j.jaci.2012.11.013) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions