Aging Stem Cells: Transcriptome Meets Epigenome Meets Methylome

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Presentation transcript:

Aging Stem Cells: Transcriptome Meets Epigenome Meets Methylome Stefan Tümpel, K. Lenhard Rudolph Cell Stem Cell Volume 14, Issue 5, Pages 551-552 (May 2014) DOI: 10.1016/j.stem.2014.04.013 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Schematic Diagram Illustrating the Effect of Aging on the Functionality of HSCs Aging-induced extrinsic factors (niche, systemic factors) and the proliferative history of stem cells itself alter the genomic properties of aging HSCs on the epigenetic and transcriptional level. This leads to characteristic phenotypic changes of aging HSCs including increases in self-renewal and clonal selection and defects in differentiation. Epigenetically induced alterations in the transcriptome of aging stem cells may thus contribute to the failure to maintain hematopoiesis and to the increasing risk of leukemogenesis during aging. Cell Stem Cell 2014 14, 551-552DOI: (10.1016/j.stem.2014.04.013) Copyright © 2014 Elsevier Inc. Terms and Conditions