An ERK-signaling process underlies HFS-induced LTP at TA-CA1 synapses.

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An ERK-signaling process underlies HFS-induced LTP at TA-CA1 synapses. An ERK-signaling process underlies HFS-induced LTP at TA-CA1 synapses. A–C, Plots of pooled and normalized data illustrating the effects of the HFS paradigm (arrow) on excitatory synaptic transmission in control conditions (A) and in the presence of the ERK inhibitor PD98059 (10 mm; B) or the PI 3-kinase inhibitor LY294002 (10 mm; C). Calibration: 0.2 mV, 100 ms. D, Histograms of the pooled data showing the relative effects of the HFS paradigm on synaptic transmission in control conditions and in the presence of either PD98059 (10 μm), U0126 (10 μm), LY294002 (10 μm), or wortmannin (50 nm). Blockade or ERK, but not PI 3-kinase, activity prevented HFS-induced LTP. Xiao Luo et al. eneuro 2015;2:ENEURO.0007-15.2015 ©2015 by Society for Neuroscience