Leptin-induced LTP involves a PI 3-kinase-dependent process.

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Leptin-induced LTP involves a PI 3-kinase-dependent process. Leptin-induced LTP involves a PI 3-kinase-dependent process. A, B, Plots of pooled and normalized data illustrating the effects of leptin on synaptic transmission in the presence of the PI 3-kinase inhibitor LY294002 (10 μm; A) or the ERK inhibitor U0126 (10 μm; B), respectively. Leptin-induced LTP was prevented following blockade of PI 3-kinase, but not ERK. Calibration: 0.2 mV, 100 ms. C, Histogram of the pooled data showing the relative effects of leptin (100 nm) on synaptic transmission in control conditions and in the presence of either LY294002 (10 μm), wortmannin (50 nm), U0126 (10 μm), or PD98059 (10 μm). Xiao Luo et al. eneuro 2015;2:ENEURO.0007-15.2015 ©2015 by Society for Neuroscience