Response to cyclosporin A (CsA) treatment and renal outcome in patients with either nongenetic or genetic disease. Response to cyclosporin A (CsA) treatment.

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Response to cyclosporin A (CsA) treatment and renal outcome in patients with either nongenetic or genetic disease. Response to cyclosporin A (CsA) treatment and renal outcome in patients with either nongenetic or genetic disease. (A) Response to CsA treatment. Patients (numbers) with complete remission (CR) are depicted in light gray, patients with partial remission (PR) are depicted in gray, and patients with no remission (NR) are depicted in black. The group of patients with genetic congenital nephrotic syndrome (CNS) /steroid–resistant nephrotic syndrome (SRNS) is further divided into patients with CNS and patients with SRNS (on the right). The two patients with nongenetic CNS were not exposed to CsA and are, therefore, not depicted in this graph. Percentages refer to CR and PR. **P<0.001. (B) Renal function in patients with either nongenetic or genetic disease depending on their response to CsA treatment. Patients (numbers) with a normal renal function at the end of the observation time are shown in light gray, patients with chronic CKD are shown in gray, and patients with ESRD are shown in black. *P=0.002; **P<0.001. Anja K. Büscher et al. CJASN 2016;11:245-253 ©2016 by American Society of Nephrology