Schematic depiction of representative sequences from enterobacterial plasmids, showing the association of carbapenemase-encoding genes with various mobile.

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Schematic depiction of representative sequences from enterobacterial plasmids, showing the association of carbapenemase-encoding genes with various mobile elements. Schematic depiction of representative sequences from enterobacterial plasmids, showing the association of carbapenemase-encoding genes with various mobile elements. (I) The blaKPC-2-containing Tn4401 transposon from plasmid pNYC (GenBank accession no. EU176011) (180). (II and III) Representative VIM-encoding sequences from plasmids pNL194 (GenBank accession no. GU585907) (167) and pCC416 (GenBank accession no. AJ704863) (59), respectively. (IV) A blaIMP-carrying sequence from plasmid pFP10-2 (GenBank accession no. HQ651093) (146). (V and VI) Sequences containing blaNDM-1 carried by a plasmid from K. pneumoniae 05-506 (GenBank accession no. FN396876) (273) and by plasmid p271A (GenBank accession no. HQ162469) (218), respectively. (VII and VIII) The OXA-48-encoding transposon Tn1999 from plasmid pA-1 (GenBank accession no. AY236073) (217) and the blaOXA-163-containing segment from plasmid p6299 (GenBank accession no. HQ700343) (216), respectively. L. S. Tzouvelekis et al. Clin. Microbiol. Rev. 2012; doi:10.1128/CMR.05035-11