CD14 polymorphisms and serum CD14 levels through childhood: A role for gene methylation? Monica Cheng Munthe-Kaas, MD, PhD, Tale Mæhre Torjussen, MD,

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Presentation transcript:

CD14 polymorphisms and serum CD14 levels through childhood: A role for gene methylation? Monica Cheng Munthe-Kaas, MD, PhD, Tale Mæhre Torjussen, MD, Kristina Gervin, MSc, Karin C. Lødrup Carlsen, MD, PhD, Kai Håkon Carlsen, MD, PhD, Berit Granum, MSc, PhD, Hanne Sagsveen Hjorthaug, MS, Dag Undlien, MD, PhD, Robert Lyle, BSc, PhD Journal of Allergy and Clinical Immunology Volume 125, Issue 6, Pages 1361-1368 (June 2010) DOI: 10.1016/j.jaci.2010.02.010 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Study design and subjects included. The different groups overlap; that is, there are children included in more than 1 analysis. Journal of Allergy and Clinical Immunology 2010 125, 1361-1368DOI: (10.1016/j.jaci.2010.02.010) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A map of CD14 showing the location of the SNPs, the amplicons and CpGs in the bisulfite sequencing, and SNP minor allele frequencies with LD plotting. Journal of Allergy and Clinical Immunology 2010 125, 1361-1368DOI: (10.1016/j.jaci.2010.02.010) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Scatter plot showing correlation between methylation level of the CpG island and sCD14 levels at 10 years. The values shown on the y-axis are the antilogs to the log methylation values. Pearson correlation = −0.224, P = .013. Journal of Allergy and Clinical Immunology 2010 125, 1361-1368DOI: (10.1016/j.jaci.2010.02.010) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Journal of Allergy and Clinical Immunology 2010 125, 1361-1368DOI: (10 Journal of Allergy and Clinical Immunology 2010 125, 1361-1368DOI: (10.1016/j.jaci.2010.02.010) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions