A New Vampire Saga: The Molecular Mechanism of T Cell Trogocytosis

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A New Vampire Saga: The Molecular Mechanism of T Cell Trogocytosis Elaine Pashupati Dopfer, Susana Minguet, Wolfgang W.A. Schamel Immunity Volume 35, Issue 2, Pages 151-153 (August 2011) DOI: 10.1016/j.immuni.2011.08.004 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 TCR Internalization and Trogocytosis in T Cells Constitutive TCR turnover occurs in resting cells. Upon stimulation, TCR nanoclusters aggregate to signaling-active microclusters that can be internalized in the pSMAC in a clathrin-dependent manner. Once the microclusters have reached the cSMAC, patches of the APC containing the pMHC molecules are trogocytosed with a TC21- and RhoG-dependent mechanism. Trogocytosed membrane proteins from the APC can be re-expressed on the T cell. Immunity 2011 35, 151-153DOI: (10.1016/j.immuni.2011.08.004) Copyright © 2011 Elsevier Inc. Terms and Conditions