Fig. 4 HRI regulates BCL11A levels.

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Fig. 4 HRI regulates BCL11A levels. HRI regulates BCL11A levels. (A) (Left) Western blot with the indicated antibodies in uninfected cells or cells infected with virus expressing scrambled or HRI shRNAs on day 15 of differentiation. (Right) BCL11A mRNA (n = 4 independent donors) and primary (1°) transcript (n = 3 independent donors) levels in HRI knockdown cells as a fraction of those in SC shRNA–expressing cells. Error bars represent SD from biological replicates. (B) BCL11A complementary DNA (cDNA) rescue in HRI-depleted HUDEP2 clonal cell lines. Data show RT-qPCR for γ-globin as a fraction of γ-globin plus β-globin. Error bars indicate SD from two biological replicates (C) HbF flow cytometry of indicated HUDEP2 sgRNA pools grown in the presence or absence of pomalidomide. Error bars indicate SEM of three biological replicates. Jeremy D. Grevet et al. Science 2018;361:285-290 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works