Community Pharmacists Monitoring of Pulmonary Tuberculosis Outpatients (Preliminary Study)

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Community Pharmacists Monitoring of Pulmonary Tuberculosis Outpatients (Preliminary Study)

Authors Usasiri Srisakul, M.Sc. in Pharm (Clinical Pharmacy) Phayom Sookaneknun, PharmD Sunantha Osiri, Ph.D Institution: Faculty of Pharmacy and Health Sciences, Mahasarakham University, Thailand, 44150 Study funded by: Health Systems Research Institute (HSRI), Thailand

Introduction DOTS (Directly Observed Treatment, Short Course) for pulmonary tuberculosis (PulTB) is a major strategy in the National Tuberculosis Programme (NTP) following WHO global plan. Thailand ranked the 16th in 22 high-burden countries.

Objectives To compare clinical outcome between Community pharmacists monitoring patients Control patients receiving normal care

Method Quasi experimental study design Patients: Preliminary study: Pulmonary Tuberculosis (PulTB) without HIV co-infection DOT category 1 (2HRZE + 4HR) December 2002 – January 2004 Mahasarakham provincial hospital Preliminary study: December 2002 – October 2003 N = 54

PulTB with DOT category1 N=54 Completed intensive treatment phase 2nd month Volunteered Community pharmacists monitoring group N=27 Control group N=27 3rd – 5th month Clinical outcomes 6th month Figure 1 Research procedure

Method (cont.) Community Pharmacists monitoring group Control group Refill of DOTS medication (1-4 weekly follow up) Pharmaceutical care Control group Normal care from the hospital (1-3 monthly follow up) Clinical outcomes Cure rate Treatment success rate Default rate Failure rate

Results: Demographic data Treatment gr. Control gr. p-value N=27 Age (year) 54.15 + 15.31 51.22 + 16.00 0.495 Male (%) 16 (47.10%) 18 (52.90%) 0.573 Smear positive (%) 17 (63.00%) 12 (44.44%) 0.172 No significant differences in all demographic data betweent both groups.

Results: Clinical outcomes Treatment gr. Control gr. p-value N=27 Cure rate 94.12% (16) 66.67% (8 ) 0.054 Treatment Success rate 96.30% (26) 74.10% (20) 0.022* Default rate 3.7% (1) 22.22% (6) 0.043* Failure rate 0% (0) 0.313 * Significant differences

Results: Clinical outcomes 0.022* 0.054 0.043* 0.313 Figure 2 Clinical outcomes

Discussion Community pharmacist monitoring can improve treatment succes rate (WHO goal > 85%), decrease default and failure rate Show the community pharmacist involvement in DOTS multidisciplinary team In the future study should be expanded number of patients, community pharmacy setting and referral system

Conclusion Community pharmacist involvement in a DOTS multidisciplinary team improved clinical outcomes in pulmonary tuberculosis outpatients.

Thank you very much