Effect of randomized treatment on all renal events (top) and the composite of all renal events, macrovascular events, or all-cause mortality (bottom) according.

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Effect of randomized treatment on all renal events (top) and the composite of all renal events, macrovascular events, or all-cause mortality (bottom) according to baseline SBP and DBP. The center of the diamond represents the estimate and its width the 95% ... Effect of randomized treatment on all renal events (top) and the composite of all renal events, macrovascular events, or all-cause mortality (bottom) according to baseline SBP and DBP. The center of the diamond represents the estimate and its width the 95% CI for overall treatment effect. Solid boxes represent estimates of treatment effect in subgroups; the centers of the boxes are placed at the estimates of effect, the areas of boxes are proportional to the number of events, and horizontal lines represent the corresponding 95% CIs. The vertical dotted line represents the point estimate for overall effect. The “P trend” tested the consistency of treatment effect in subgroups. Bastiaan E. de Galan et al. JASN 2009;20:883-892 ©2009 by American Society of Nephrology