Volume 69, Issue 7, Pages (April 2006)

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Volume 69, Issue 7, Pages 1222-1228 (April 2006) Longer treatment time and slower ultrafiltration in hemodialysis: Associations with reduced mortality in the DOPPS R. Saran, J.L. Bragg-Gresham, N.W. Levin, Z.J. Twardowski, V. Wizemann, A. Saito, N. Kimata, B.W. Gillespie, C. Combe, J. Bommer, T. Akiba, D.L. Mapes, E.W. Young, F.K. Port Kidney International Volume 69, Issue 7, Pages 1222-1228 (April 2006) DOI: 10.1038/sj.ki.5000186 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 (a) Distribution of facility mean TT, by region and phase of DOPPS (n=546 facilities). (b) Distribution of facility mean UFR, by region and phase of DOPPS (n=531 facilities). Kidney International 2006 69, 1222-1228DOI: (10.1038/sj.ki.5000186) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 2 RR of all-cause mortality, by TT category. The incremental RR of mortality with decreasing TT categories in all DOPPS regions combined. The referent category is TT>4 h (240 min). Kidney International 2006 69, 1222-1228DOI: (10.1038/sj.ki.5000186) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 3 RR of mortality and TT, by region. The RR of mortality (on a log scale) and TT by region (overall RR=0.93 per 30 min (P<0.0001). Although the association was statistically significant in each region, it was strongest in Japan (RR=0.84 per 30 min; P<0.0001), followed by Europe (RR=0.94 per 30 min; P=0.01) and the United States (RR=0.96 per 30 min; P=0.04). The thick solid lines represent the highest concentration of patients in each distribution (50% or more); the thin solid lines represent 10–25% of patients; the dotted lines represent the lowest concentration of patients (<10%). Kidney International 2006 69, 1222-1228DOI: (10.1038/sj.ki.5000186) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 4 Interaction between Kt/V and TT. The incremental RR of mortality (on a log scale) by TT (x-axis) for patients in three different categories of Kt/V (interaction P=0.007), illustrating that the effect of TT is greater at higher Kt/V. Kidney International 2006 69, 1222-1228DOI: (10.1038/sj.ki.5000186) Copyright © 2006 International Society of Nephrology Terms and Conditions