Fig. 5 Mutation of Y281ENV motif in FcRL1 impairs BCR engagement–induced B cell activation in the absence of FcRL1 ligation. Mutation of Y281ENV motif.

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Fig. 5 Mutation of Y281ENV motif in FcRL1 impairs BCR engagement–induced B cell activation in the absence of FcRL1 ligation. Mutation of Y281ENV motif in FcRL1 impairs BCR engagement–induced B cell activation in the absence of FcRL1 ligation. Left: Representative TIRFM images showing the synaptic recruitment of BCRs (A), pSyk (C), pBLNK (E), and pPI3K (p85α) (G) in FcRL1-KO primary B cells expressing HA-FcRL1(WT)-YFP and HA-FcRL1(Y281F)-YFP chimeric receptors. Scale bars, 1.5 μm. Right: Quantitative analysis of the mFI of synaptic BCRs (B) (n = 34 to 36 cells), pSyk (D) (n = 72 to 77 cells), pBLNK (F) (n = 76 to 96 cells), and pPI3K (p85α) (H) (n = 60 to 75 cells). Experiments were repeated three times, and data from a representative experiment are shown. Bar represents means ± SEM. Two-tailed Student’s t tests were used for the statistical comparisons. Xingwang Zhao et al. Sci Adv 2019;5:eaaw0315 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).