Chromothripsis Current Biology Emily M. Hatch, Martin W. Hetzer  Current Biology  Volume 25, Issue 10, Pages R397-R399 (May 2015) DOI: 10.1016/j.cub.2015.02.033 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 Model of the micronucleation mechanism of chromothripsis. When a chromosome missegregates during mitosis in mammalian cells and forms a micronucleus (MN) (A), it can undergo extensive DNA fragmentation as a result of nuclear envelope disruption in interphase (B). This damaged chromosome can segregate with the rest of the chromatin and end in up in the primary nucleus (PN) after the next mitosis. At that point it can undergo non-homologous end joining to generate a highly rearranged chromosome in which some sequences have been lost (C). Current Biology 2015 25, R397-R399DOI: (10.1016/j.cub.2015.02.033) Copyright © 2015 Elsevier Ltd Terms and Conditions