Activation of Erk1/2 in cortical neurons of mouse PD/DLB model and human DLB patient. Activation of Erk1/2 in cortical neurons of mouse PD/DLB model and.

Slides:

Advertisements

Similar presentations

Posttranslational regulation of ETV5 and c-JUN in neurons.

Advertisements

PDE5A is expressed by podocytes.

Characterization of transgenic mice.

Dendritic spine density at P30 is elevated on isolated PirB−/− neurons in layer 2/3 after sparse excision of PirB at E15.5. Dendritic spine density at.

Density of dendritic spines on L2/3 pyramidal neurons is greater in visual cortex of germline PirB−/− mice than in PirB+/+ mice at P30. Density of dendritic.

DH E2 infusion significantly increased phosphorylation of the p42 isoform of ERK (A) and of Akt (B) in the DH of OVX females, but not sham GDX males. DH.

Fig. 3 Biological function of TG2 and the interaction with MT-2.

Adult (2- to 4-mo-old) Nlgn3y/– mice modify the social behavior of their littermates. Adult (2- to 4-mo-old) Nlgn3y/– mice modify the social behavior of.

MN-enriched miRNAs are depleted temporally in ALS rodent model and human patient spinal cord. MN-enriched miRNAs are depleted temporally in ALS rodent.

Active avoidance is impaired in aged mice in both multimodal and visual versions of the task. Active avoidance is impaired in aged mice in both multimodal.

Fig. 5. Nutlin-3 treatment rescues the proliferation and differentiation of NPCs in vitro. Nutlin-3 treatment rescues the proliferation and differentiation.

Volume 21, Issue 1, Pages (January 2013)

A–E, Active avoidance (A–D) and optokinetic testing (E) in an independent cohort. A–E, Active avoidance (A–D) and optokinetic testing (E) in an independent.

Phosphorylation levels of discoidin domain receptor (DDR)2.

Effects of E2 on levels of phospho-CREB in the DH of OVX females, sham males, and GDX males. Effects of E2 on levels of phospho-CREB in the DH of OVX females,

Sparse excision of PirB at E15

Neuronal ATM level is reduced in mouse models of AD

Symptomatic rescue of double‐transgenic mice without decreased protein aggregation The expression of exogenous HMGB1‐FLAG (detected with an anti‐FLAG antibody)

C/EBPβ regulates FAM134B-2 and autophagy regulators in the mouse liver

MET/β-catenin complexes during synapse development.

Leptin and amylin signaling.

Immunohistochemistry of human DLB brains.

FGF21 signaling in hypothalamus is blocked by FGFR1 neutralizing antibody. FGF21 signaling in hypothalamus is blocked by FGFR1 neutralizing antibody. Twelve-week-old.

Spatial statistics of X-ray volumes reveal layering and spatially diverse distribution of cell bodies. Spatial statistics of X-ray volumes reveal layering.

HGF recruits additional synapsin 1 to MET receptor complex.

CK2 phosphorylates mammalian FMRP S499.

Fig. 2. Deficiency of neuronal HS leads to reduced neuroinflammation.

Activation of glial cells.

APT1 palmitoylation and localization.

Axial MR image (TR/TE, 10,002/142) obtained when the patient was aged 5 days shows extensive areas of abnormal signal intensity, which suggest edema involving.

Western blot analysis of α-Syn-BAC-Tg/GBA-hetero-KO mice at multiple time points. Western blot analysis of α-Syn-BAC-Tg/GBA-hetero-KO mice at multiple.

Increased proIGF-II and decreased IGF-IIR in BTBR compared with B6 mice. Increased proIGF-II and decreased IGF-IIR in BTBR compared with B6 mice. Western.

Increased phosphorylation of Akt, Girdin S1416, and NR2B of NMDA receptor in the hippocampus of mouse after fear conditioning. Increased phosphorylation.

Peli1 levels are reduced in bid−/− microglia upon LPS stimulation.

The number of swim cycles showed no correlation with the resting membrane potentials of the CPG neurons. The number of swim cycles showed no correlation.

PGC-1α isoforms. PGC-1α isoforms. A, The illustration of PGC-1α new alternative exons and known exons in RefSeq/Ensembl/UCSC genome references. Human ESTs.

Involvement of the frontal and parietal lobes in patients with isolated cortical hyperintensities. Involvement of the frontal and parietal lobes in patients.

IOP is not affected by microfibril deficiency.

Csmd2 mRNA is expressed in the mouse forebrain.

Chronological changes of pSer46-MARCKS in human α-Syn-BAC-Tg/GBA-hetero-KO mice. pSer46-MARCKS and pSer129-α-Syn were costained in human normal α-Syn-BAC-Tg/glucocerebrosidase.

Fig. 3 Biological function of TG2 and the interaction with MT-2.

Synaptic density is significantly impaired in male FBN-ARO-KO mice.

Western blot of MDA-modified proteins in FVB control, OVE26 diabetic, and catalase-protected OVE26C diabetic hearts. Western blot of MDA-modified proteins.

Aβ-mediated Ras-MAPK signaling and Cyclin D1 expression in B103 cells are dependent on APP expression and can be reversed with MEK or Ras inhibition. Aβ-mediated.

Mek-1/2 activity mediates stress-enhanced Erk-1/2 phosphorylation and fear conditioning. Mek-1/2 activity mediates stress-enhanced Erk-1/2 phosphorylation.

Reduction of PGC-1α isoforms, SDHA, and Tomm20 in PD

Inducible liver-specific insulin receptor knockout (iLIRKO) shows insulin resistance in the liver and extrahepatic tissues. Inducible liver-specific insulin.

Oligomeric Aβ42 treatment induces expression of Ras and Cyclin D1 and activation of ERK in primary rat cortical neurons. Oligomeric Aβ42 treatment induces.

TRAF6 enhances I/R-induced oxidative stress.

Arctigenin decreased Aβ content and inhibited BACE1 translation in APP/PS1 AD mice. Arctigenin decreased Aβ content and inhibited BACE1 translation in.

nAChR β2 antibody labeling in WT and β2 KO mouse model.

TBS- and HFS activate different signaling pathways.

MET-1 increases DRG neuron K+ currents.

TOMA does not affect NFTs in posterior hypothalamus or cortex.

The dopamine (DA) response to cocaine infusion in the NAc in constitutive p11 KO mice is restored by nicotinic or muscarinic receptor stimulation in the.

High titers of peripheral anti-Aβ antibodies do not reduce Aβ deposits in aged Tg-SwDI mice. High titers of peripheral anti-Aβ antibodies do not reduce.

Expression of human tau in GFAP/tau Tg mice.

Notch1 signaling mediates the neuronal induction of BLBP promoter transcription in glia. Notch1 signaling mediates the neuronal induction of BLBP promoter.

Both the MMP9 and MMP2 systems are activated by anti-Aβ antibodies, IVIg, and mouse IgG. Both the MMP9 and MMP2 systems are activated by anti-Aβ antibodies,

At P23, dendritic spine density on L2/3 pyramidal cells in PirB−/− visual cortex is similar to that of PirB+/+. At P23, dendritic spine density on L2/3.

Images of a 22-month-old male patient with severe left temporal lobe epilepsy that was recognized at age 9 months after bacterial meningitis at age 6 months.A.

Depletion of Gr-1+ neutrophils by systemic anti-Gr-1 treatment prevents exacerbated neurodegeneration in RAG1-KO mice. Depletion of Gr-1+ neutrophils by.

Gene expression in the PFC of mice with an inducible neuron-specific bdnf knock-out in embryogenesis. Gene expression in the PFC of mice with an inducible.

PC loss in Nhe6-null mouse cerebellum, female and male.

Passive immunization with CT α-syn antibodies improved TH pathology and neuroinflammation in the striatum of α-syn tg mice. Passive immunization with CT.

ΔFosB regulates spike number in hippocampal CA1 neurons.

Repulsive Guidance Molecule-a Is Involved in Th17-Cell-Induced Neurodegeneration in Autoimmune Encephalomyelitis Shogo Tanabe, Toshihide Yamashita Cell.

BDNF protein is expressed in neurons and astrocytes of hippocampus after pilocarpine-induced SE. A, Representative confocal images of hippocampal subfields.

NSG2 interacts with AMPAR subunits GluA1 and GluA2.

Toll-like receptor 4 (TLR4)-knockout (KO) mice were partially protect against rotenone-induced enteric glial inflammation and α-syn expression in the colon.

Presentation transcript:

Activation of Erk1/2 in cortical neurons of mouse PD/DLB model and human DLB patient. Activation of Erk1/2 in cortical neurons of mouse PD/DLB model and human DLB patient. A, Costaining of occipital cortex tissues from α-Syn-BAC-Tg/GBA-hetero-KO (Tg) or the nontransgenic sibling control (non-Tg) mice at 1, 6, and 24 months of age, by antibodies against Erk1/2 active forms (pThr202/Tyr204-Erk1 and pThr185/Tyr187-Erk2) and against pSer46-MARCKS. Right graph shows quantitative analysis of pErk1/2 signal intensities in 3 mice (10 visual fields for mean value of each mouse). Statistical analyses were performed with two-way ANOVA followed by Student’s t test; *, p < 0.05; **, p < 0.01. B, Costaining of pSer46-MARCKS with MAP2 or GFAP in mouse cortex. C, The similar costaining of pErk1/2 and pSer46-MARCKS in human temporal lobe from DLB patients and non-neurologic disease controls. D, Western blot analyses of whole cortex tissues from α-Syn-BAC-Tg/GBA-hetero-KO (Tg) or non-Tg mice at 1, 6, and 24 months of age with anti-pErk1/2 and -Erk1/2 antibodies. E, The similar Western blot analyses of temporal lobes from human DLB patients. Kyota Fujita et al. eNeuro 2018;5:ENEURO.0217-18.2018 ©2018 by Society for Neuroscience