Transgenic expression of mCREB or CREB produces opposite effects in the learned helplessness model of depression. Transgenic expression of mCREB or CREB.

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Transgenic expression of mCREB or CREB produces opposite effects in the learned helplessness model of depression. Transgenic expression of mCREB or CREB produces opposite effects in the learned helplessness model of depression. Single (tTA+/mCREB− or tTA+/CREB−) or bitransgenic (tTA+/mCREB+ or tTA+/CREB+) mice were exposed to sham treatment or IES and subsequently tested in an active avoidance paradigm (30 trials of 30 sec duration). The results demonstrate that there is a significant reduction in the number of escape failures and the latency to escape in the mCREB bitransgenic mice and that the opposite phenotype is observed in the CREB bitransgenic mice. There was no difference in escape failures or latency between the sham-treated single or bitransgenic animals, indicating that the alteration in active avoidance behavior is a specific response to IES exposure. The results are presented as the mean ± SEM for each group (n = 8–15 per group). *p < 0.05 compared with single transgenic mice (ANOVA and Fisher's post hoc test). Samuel S. Newton et al. J. Neurosci. 2002;22:10883-10890 ©2002 by Society for Neuroscience