Receptor tyrosine kinase (RTK) responds to external stimuli including extracellular matrix components and chemokines and subsequently activates phosphoinositide.

Slides:

Advertisements

Similar presentations

Rho family GTPases Thuy Nguyen 3/6/2012

Advertisements

Ligand Receptor Cortisol Receptor is located in the cytosol Retinoid Receptors are in the nucleus Target gene in the nucleus Regulation of Transcription.

Cell Migration Tom Paine March 16, Will cover papers on single cell migration, adhesion- dependent trafficking and collective cell migration. Single.

Chemotaxis of Eukaryotic Cells: 1.Dictyostelium discoideum

Chemotaxis of Eukaryotic Cells: 1.Dictyostelium discoideum - Part 2

Chemotaxis of Eukaryotic Cells:

Introduction to Signaling Networks Biophysics 702, February 2012 Jonathan P Butchar.

Cell Signaling Pathways – A Case Study Approach

Advances in Molecular Biology of Lung Disease

G protein–coupled receptors

Regulation of platelet plug formation by phosphoinositide metabolism

Eph-Ephrin Bidirectional Signaling in Physiology and Disease

You have identified a novel cytoplasmic protein

Rho-GTPases and downstream effector proteins involved in cell motility

SOX11 holds mantle cell lymphoma’s key to home

Signal Transduction Through the Epidermal Growth Factor Receptor

Figure 3 Defects in the T cell receptor signalling pathway

Volume 73, Issue 5, Pages (March 2008)

Figure 2 Intracellular actions of metformin

Figure 3 Integrative signalling networks enable interactions

Nat. Rev. Nephrol. doi: /nrneph

The pathway signalling starts with the binding of insulin or growth factors to insulin receptors. The pathway signalling starts with the binding of insulin.

Development of PI3K/AKT/mTOR Pathway Inhibitors and Their Application in Personalized Therapy for Non–Small-Cell Lung Cancer Vassiliki Papadimitrakopoulou,

Transcriptional inflammatory response to hypoxia and cellular necrosis

Schematic view of Trk receptors signalling, showing the three major pathways involved in cell differentiation and survival. Schematic view of Trk receptors.

Platelet-derived growth factor receptors (PDGFRs) and ligand patterns.

PTEN Enters the Nuclear Age

Figure 1 The insulin signalling pathway

Rab5 and Rac Team Up in Cell Motility

Inhibition of mammalian target of rapamycin: Two goals with one shot?

In chronic haemorrhage a) several pigmented macrophages fill the alveoli with dense fibrosis of the interstitium; b) the haemosiderin pigment in macrophages.

Nat. Rev. Urol. doi: /nrurol

Nat. Rev. Urol. doi: /nrurol

Flowchart showing the requirement for starting, documenting and evaluating the effect on quality of life (QoL) of interdisciplinary best supportive care.

Familial history of hereditary haemorrhagic telangiectasis (HHT) of the 29-yr-old patient (•) with HHT and severe pulmonary arterial hypertension (PAH).

Oesophageal pleural fistula in a patient with Crohn's disease

mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells

Nat. Rev. Nephrol. doi: /nrneph

Live Longer sans the AT1A Receptor

Signal Transduction Through the Epidermal Growth Factor Receptor

AKT/PKB Signaling: Navigating Downstream

Signalling links in the liver: Knitting SOCS with fat and inflammation

A) Healthcare utilisation, b) short form (SF)-12 scores and c) work productivity and activity impairment in patients with asthma (▓) and diabetes (▪) in.

Inflammatory responses elicited by e-liquid vaping.

3-year survival of lung cancer patients in the general population and in those with a prior diagnosis of chronic obstructive pulmonary disease (COPD).

Immune reconstitution inflammatory syndrome (IRIS) associated with Mycobacterium tuberculosis (TB) infection. a) In healthy individuals in response to.

Positron emission tomography scan in the axial plane performed in June 2007 showing intense and homogeneous increased uptake of 18-fluorodeoxyglucose within.

Summary of this study. Summary of this study. Cysteinyl-leukotrienes (cys-LTs) stimulate mitogenesis of bronchial fibroblasts only in the presence of RTK.

Schematic diagram of endothelin (ET)-1 release in the human cardiovascular system. Schematic diagram of endothelin (ET)-1 release in the human cardiovascular.

Platelet-derived growth factor (PDGF) signalling pathway.

Morphological subtypes of cyst-related primary lung malignancies

A) Measurement of the right atrial a) area and b) long axis for calculation of right atrial volume. c) Measurement of the left ventricular eccentricity.

Endobronchial biopsy from case 2 showing sheets of epitheloid macrophages without giant cells, mixed with other chronic inflammatory cells. Endobronchial.

Proportion of patients in each World Health Organization functional class (WHO-FC) at the time of pulmonary arterial hypertension-associated systemic sclerosis.

Oxidative stress and corticoresistance.

The mitogen-activated protein kinase (MAPK) pathway showing mutations identified in pulmonary Langerhans cell histiocytosis (PLCH). The mitogen-activated.

Two Poles and a Compass Cell

Dysregulation of the mTOR Pathway Secondary to Mutations or a Hostile Microenvironment Contributes to Cancer and Poor Wound Healing Richard A.F. Clark,

Overall forest plot from meta-analysis carried out in 11 studies a) assessing the relative risk of adverse events; and subgroup analysis performed on studies.

Cell migration is mediated by Rho-GTPase protein activity.

Pro-proliferative effect of lipoxin A4 (LXA4) is phosphatidylinositol 3′-kinase dependent and mediated by ALX/formyl peptide L1 receptor. 100 nM LXA4 promoted.

The cyctoprotective endoplasmic reticulum (ER) stress mechanism [32].

Rho and Rac Take Center Stage

Risk ratio (RR) and number needed to treat (NNT) are time-dependent measures. a) When an intervention is associated with constant relative risk reduction.

Bronchial biopsy from patient 5 (a; Haematoxylin-Eosin-Safran stain and ×10 growth). Bronchial biopsy from patient 5 (a; Haematoxylin-Eosin-Safran stain.

Pathogenic concepts of pulmonary arterial hypertension (PAH).

Signaling pathways of galanin receptors.

24-h blood pressure profile after a, d) one night of intermittent hypoxia (IH) exposure, b, e) 13 nights IH exposure and c, f) 5 days after cessation of.

Pulmonary artery pressure in a) healthy subjects and b) pulmonary hypertension (PH) subjects. Pulmonary artery pressure in a) healthy subjects and b) pulmonary.

Mean change from baseline in percentage predicted forced vital capacity (FVC) in the a) phase III CAPACITY [27] and b) ASCEND [14] studies. #: n=174; ¶:

Presentation transcript:

Receptor tyrosine kinase (RTK) responds to external stimuli including extracellular matrix components and chemokines and subsequently activates phosphoinositide 3-kinase (PI3K) to produce phosphatidylinositol (3,4,5)-trisphosphate (PIP3). Receptor tyrosine kinase (RTK) responds to external stimuli including extracellular matrix components and chemokines and subsequently activates phosphoinositide 3-kinase (PI3K) to produce phosphatidylinositol (3,4,5)-trisphosphate (PIP3). This, in turn, activates Rho-guanine nucleotide exchange factors (GEF), mediating Rho-GTPase activation and cell migration. Wild-type p53, via phosphatase and tensin homologue (PTEN), negatively regulates PI3K activity and Rho-GTPase-mediated cell migration. Adapted from [13]. Fraser R. Millar et al. Eur Respir Rev 2017;26:160069 ©2017 by European Respiratory Society