Cardiorespiratory fitness is associated with SiOGTT, GSISOGTT, and DIOGTT. VO2max was measured during incremental workload and exhaustive aerobic exercise.

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Presentation transcript:

Cardiorespiratory fitness is associated with SiOGTT, GSISOGTT, and DIOGTT. VO2max was measured during incremental workload and exhaustive aerobic exercise in subjects representative of a heterogeneous population with respect to age, BMI, adiposity, and glucose tolerance status (white circles, NGT; light-gray squares, IGT; and dark-gray triangles, T2D). Cardiorespiratory fitness is associated with SiOGTT, GSISOGTT, and DIOGTT. VO2max was measured during incremental workload and exhaustive aerobic exercise in subjects representative of a heterogeneous population with respect to age, BMI, adiposity, and glucose tolerance status (white circles, NGT; light-gray squares, IGT; and dark-gray triangles, T2D). VO2max was directly associated with SiOGTT (y = 0.00117x + 0.0119) (A) but had an inverse curvilinear log-log relationship with early-phase (log10y = −0.39 log10x + 5.18) (B) and late-phase (log10y = −0.42 log10x + 6.07) (C) GSISOGTT. Finally, there were direct linear relationships between VO2max and early-phase (y = 27.8x + 916) (D) and late-phase (y = 200x + 5,966) (E) DIOGTT, a measure of pancreatic β-cell insulin secretory compensation for changing insulin sensitivity. Solid and dotted lines represent the regression curves and 95% CIs, respectively, and show unadjusted data. Thomas P.J. Solomon et al. Dia Care 2015;38:921-929 ©2015 by American Diabetes Association