Prof. Jean-Marc Nabholtz, MD, MSc Chairman

Cancer Therapy Development Addition to Prior standard NEW SINGLE AGENT MBC ADJUVANT Nabholtz, May, 2001

Evolution BCIRG is the Breast Cancer division of CIRG (Cancer International Research Group) Present evaluation of potential other divisions Disease sites eg. LCIRG, GICIRG… Mechanistic groups: Kinase Inhibitors IRG …others?... Integration of activities in Global Translational Processes. with UCLA/JCCC and other Universities Development of Translational Tools (Cancer International Tumor Bank)….

Global Translational Processes

Multistep Process: 7 major steps 1. Identification of Gene abnormalities 2. Determination of relevance in human cancers 3. Pathway Identification 4. Identification of therapeutic interventions 5. Identifications of patients sub-populations with given abnormality / Tests 6. Identification of predictive factors / Tests 7. Pivotal clinical development

Translationnal Multistep Process (7 of 7) Pivotal Global Clinical Development Acces to multiple targeted subpopulations in a timely fashion for proof of concept in humans CIRG First Academic Global Translational Intergroup

Meeting the Challenges Phenomenal acceleration of new compounds Emergence of targeted therapies in subpopulations Concept of biology based individualized therapy Need to define new models of development and define new translational strategies Patient Access Overall stable number of patients Targeted therapies: Need to study subpopulations Need for new processes for developing new drugs

Summary: Science is our guide BCIRG and CIRG were created to meet that need The concept has been proven to work Integrated Translational approach Academic Global Translational collaboration