Serum anti-neuronal antibodies (anti-N) in patients with positive serum anti-GRP78. Serum anti-neuronal antibodies (anti-N) in patients with positive serum anti-GRP78. Patients with serum anti-GRP78 exceeding the mean+2 SD of healthy control group (9.0 U/mL) were defined as positive, including 10 patients with diffuse neuropsychiatric SLE (NPSLE) and in seven patients with lupus nephritis (LN). Serum anti-N levels were compared between these two groups. Statistical analysis was performed by Mann-Whitney U test. Yu Matsueda et al. Lupus Sci Med 2018;5:e000281 ©2018 by Lupus Foundation of America