Effects of Smo and Math5 double mutations on RGC and cone cell production. Effects of Smo and Math5 double mutations on RGC and cone cell production. A–P,

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Effects of Smo and Math5 double mutations on RGC and cone cell production. Effects of Smo and Math5 double mutations on RGC and cone cell production. A–P, Immunofluorescent labeling of cell markers in control and different mutant retinas at E17.5. Sections from the control double heterozygous (Smo+/flox; Math5+/Cre with Chx10-Cre) (A, E, I, M), Smo single mutants (Smoflox/flox; Math5+/Cre with Chx10-Cre) (B, F, J, N), Math5 single mutants (Smo+/flox; Math5Cre/Cre with Chx10-Cre) (B, F, J, N), and Smo Math5 double mutants (Smoflox/flox; Math5Cre/Cre with Chx10-Cre) (D, H, L, P) were labeled for DAPI (A–D), GFP (E–H), Brn3a (I–L), and GγC (M–P). gcl, Ganglion cell layer; vz, ventricular zone. Scale bar: (in A) A–P, 100 μm. Q–T, Quantification of RGC and photoreceptor marker-positive cells by flow cytometry in single- and double-mutant retinas at E17.5. Q–S, Bar graphs show percentages of marker-positive cells among total cells. Genotypes of the retinas are (1) double heterozygous (Smo+/flox; Math5+/Cre with Chx10-Cre), (2) Smo single mutants (Smoflox/flox; Math5+/Cre with Chx10-Cre), (3) Math5 single mutants (Smo+/flox; Math5Cre/Cre with Chx10-Cre), and (4) Smo Math5 double mutants (Smoflox/flox; Math5Cre/Cre with Chx10-Cre). The numbers (n) of individual retinas analyzed are indicated below the bar graphs. T, A table lists p values for different markers according to statistical analyses among various genotypes. N.S., Not significant. Error bars indicate SEM. Kiyo Sakagami et al. J. Neurosci. 2009;29:6932-6944 ©2009 by Society for Neuroscience