Syndecan-1: A Quantitative Marker for the Endotheliopathy of Trauma

Slides:

Advertisements

Similar presentations

Physician-Owned Surgical Hospitals Outperform Other Hospitals in Medicare Value- Based Purchasing Program Adriana G. Ramirez, MD, Margaret C. Tracci,

Advertisements

Martin A. Makary, MD, MPH, J. Bryan Sexton, PhD, Julie A

The Hartford Consensus: Survey of the Public and Healthcare Professionals on Active Shooter Events in Hospitals Lenworth M. Jacobs, MD, MPH, FACS, Karyl.

Lenworth M. Jacobs, MD, MPH, FACS, Karyl J

Trend in Volume of Urologic Prosthetic Surgery after Initiation of Prostate Cancer Survivorship Program Alison M. Rasper, MD, Kara E. McAbee, MD, Marc.

Biologic vs Synthetic Inguinal Hernia Repair: 1-Year Results of a Randomized Double- Blinded Trial Grant V. Bochicchio, MD, MPH, FACS, Ajay Jain, MD,

A Prospective Randomized Trial of Ultrasound- vs Landmark-Guided Central Venous Access in the Pediatric Population Matias Bruzoni, MD, Bethany J. Slater,

Simple Suturing Technique for Umbilical Dimple Wound after Single-Incision Laparoscopic Surgery Yoichi Matsui, MD, PhD, Sohei Satoi, MD, PhD, FACS, Satoshi.

Procedure-Specific Trends in Surgical Outcomes

Predicting Pediatric Patients Who Require Care at a Trauma Center: Analysis of Injuries and Other Factors Andrea N. Doud, MD, Samantha L. Schoell, PhD,

Reduced Postoperative Chronic Pain after Tension-Free Inguinal Hernia Repair Using Absorbable Sutures: A Single-Blind Randomized Clinical Trial Igor.

Exploring the Relationship Between Stereotype Perception and Residents' Well-Being Arghavan Salles, MD, PhD, Claudia M. Mueller, PhD, MD, FACS, Geoffrey.

Michael T. Kassin, MD, Rachel M. Owen, MD, Sebastian D

Lisa M. Kodadek, MD Journal of the American College of Surgeons

Mary J. Edwards, MD, FACS, Michael Lustik, MS, Mark W

Defining Dogma: Quantifying Crystalloid Hemodilution in a Prospective Randomized Control Trial with Blood Donation as a Model for Hemorrhage Samuel Wade.

Preoperative Standard Oral Nutrition Supplements vs Immunonutrition: Results of a Systematic Review and Meta-Analysis Refaat A. Hegazi, MD, PhD, MPH,

Simple Suturing Technique for Umbilical Dimple Wound after Single-Incision Laparoscopic Surgery Yoichi Matsui, MD, PhD, Sohei Satoi, MD, PhD, FACS, Satoshi.

Introduction of Mechanical Sphincter Augmentation for Gastroesophageal Reflux Disease into Practice: Early Clinical Outcomes and Keys to Successful Adoption

Are Surgeons Being Paid Fairly by Medicaid

Frailty as a Predictor of Surgical Outcomes in Older Patients

Assessment of Microglial Activation Patterns and Their Potential as an In Vivo Marker of Traumatic Brain Injury Severity Christopher M. Schneider, MD,

Remediation of Radiation-Associated Vasculopathy Utilizing a Novel Angiogenic Nanotechnology Alicia E. Snider, MD, Alexis Donneys, MD, Kavitha Ranganathan,

A Patient-Centered Early Warning System to Prevent Readmission after Colorectal Surgery: A National Consensus Using the Delphi Method Linda T. Li, MD,

Perceived Complexity of Various Liver Resections: Results of a Survey of Experts with Development of a Complexity Score and Classification Major K. Lee,

Nonclinical Factors Associated with 30-Day Mortality after Lung Cancer Resection: An Analysis of 215,000 Patients Using the National Cancer Data Base

Creating Individual Surgeon Performance Assessments in a Statewide Hospital Surgical Quality Improvement Collaborative Christopher M. Quinn, MS, Karl.

Racial and Regional Disparities in the Effect of the Affordable Care Act's Dependent Coverage Provision on Young Adult Trauma Patients John W. Scott,

Gastric Perforation Associated with Bilateral Inguinal Hernias

Maureen V. Hill, MD, Ryland S. Stucke, MD, Sarah E

Taking Control of Your Surgery: Impact of a Prehabilitation Program on Major Abdominal Surgery Ryan Howard, MD, Yue S. Yin, BS, Lane McCandless, BS,

Generation of an Actionable, Preoperative Risk Prediction and Cost Model for Incisional Hernia Using Longitudinal Multi-Hospital Health Data John P.

Correction Journal of the American College of Surgeons

One-year results of thoracic endovascular aortic repair for blunt thoracic aortic injury (RESCUE trial) Ali Khoynezhad, MD, PhD, FACS, Carlos E. Donayre,

Complications of Pediatric Cholecystectomy: Impact from Hospital Experience and Use of Cholangiography Lorraine I. Kelley-Quon, MD, MSHS, Adrian Dokey,

Enhancing Patient Outcomes while Containing Costs after Complex Abdominal Operation: A Randomized Controlled Trial of the Whipple Accelerated Recovery.

Changing Surgical Trends in Young Patients with Early Stage Breast Cancer, 2003 to 2010: A Report from the National Cancer Data Base Catherine E. Pesce,

Timed Stair Climbing Is the Single Strongest Predictor of Perioperative Complications in Patients Undergoing Abdominal Surgery Sushanth Reddy, MD, FACS,

Joanna Grudziak, MD, Carolyn Snock, Tayamika Zalinga Phiri, Jared R

Correction Journal of the American College of Surgeons

Access Delayed Is Access Denied: Relationship Between Access to Trauma Center Care and Pre-Hospital Death Zain G. Hashmi, MBBS, Molly P. Jarman, PhD,

Lisa M. Knowlton, MD, MPH, FRCSC, Arden M

Kathryn A. Schlosser, MD, Michael R

Thomas J. Birdas, MD, MBA, FACS, Grace F

The Impact of Neutrophil-to-Lymphocyte Ratio on Mortality in Critically Ill Trauma Patients Evren Dilektasli, MD, Kenji Inaba, MD, FACS, Tobias Haltmeier,

Military surgeons just want to have fun

Markers of Systemic Inflammatory Response Are Prognostic Factors in Patients with Pancreatic Neuroendocrine Tumors (PNETs): A Prospective Analysis Apostolos.

Cordelie E. Witt, MD, Ali Rowhani-Rahbar, MD, PhD, Frederick P

Assessing Learning During Morbidity and Mortality Conference with a Real-time Response System Ira L. Leeds, MD, Sandra DiBrito, MD, Christian Jones,

Exploring the Relationship Between Stereotype Perception and Residents' Well-Being Arghavan Salles, MD, PhD, Claudia M. Mueller, PhD, MD, FACS, Geoffrey.

Fifteen-Year Trauma System Performance Analysis Demonstrates Optimal Coverage for Most Severely Injured Patients and Identifies a Vulnerable Population

Significant Variation in Surgical Supply Cost Secondary to Surgeon Preference for Laparoscopic Cholecystectomy Michelle C. Nguyen, MD, Matthew J. Luzum,

Timing of Complications and Length of Stay after Rectal Cancer Surgery

John-Michael Gamble, BScPharm, MSc, Dean T. Eurich, PhD, Thomas J

David J. Hall, MD, Kevin R. Olsen, MD, Juan C. Mira, MD, Patrick W

Patient Reported Outcomes after Ventral Hernia Repair: A Modular Approach to Designing a Qualitative Assessment Tool Martin J. Carney, Kate E. Golden,

Outcomes after Pancreatectomy with Routine Pasireotide Use

Angela M. Ingraham, MD, Mark E. Cohen, PhD, Mehul V

High Risk of Catastrophic Health Expenditure among Uninsured Emergency Surgery Patients in the United States John W. Scott, MD, MPH, Joaquim M. Havens,

Comparison of Hospital Performance in Emergency Versus Elective General Surgery Operations at 198 Hospitals Angela M. Ingraham, MD, Mark E. Cohen, PhD,

Trimodal Distribution of Trauma Deaths Is No More

Excision with Split-Thickness Skin Graft and Negative-Pressure Therapy for the Treatment of Hidradenitis: A Potential Cure? Robert T. Nevitt, MD, Lauren.

Personal Consequences of Malpractice Lawsuits on American Surgeons

Journal of the American College of Surgeons

Blake Cady, MD, Thomas Miner, MD, Abraham Morgentaler, MD

Trauma: Still the Cornerstone of Acute Care Surgery Specialty

Trauma: Still the Cornerstone of Acute Care Surgery Specialty

Impact of Resident Involvement in Surgery (IRIS-NSQIP): Looking at the Bigger Picture Based on the American College of Surgeons-NSQIP Database Antoine.

Evidence-Based Bundled Quality Improvement Intervention for Reducing Surgical Site Infection in Lower Extremity Vascular Bypass Procedures Katherine.

Ruchi Thanawala, MD, Jonathan L. Jesneck, PhD, Gladys L

Presentation transcript:

Syndecan-1: A Quantitative Marker for the Endotheliopathy of Trauma Erika Gonzalez Rodriguez, MD, Sisse R. Ostrowski, MD, DMSc, Jessica C. Cardenas, PhD, Lisa A. Baer, BSc, Jeffrey S. Tomasek, MD, Hanne H. Henriksen, BSc, Jakob Stensballe, MD, PhD, Bryan A. Cotton, MD, MPH, FACS, John B. Holcomb, MD, FACS, Pär I. Johansson, MD, DMSc, Charles E. Wade, PhD Journal of the American College of Surgeons Volume 225, Issue 3, Pages 419-427 (September 2017) DOI: 10.1016/j.jamcollsurg.2017.05.012 Copyright © 2017 The Authors Terms and Conditions

Figure 1 CONSORT (Consolidated Standards of Reporting Trials)-like diagram showing the selection process used to identify trauma patients for inclusion in the study. EoT, endotheliopathy of trauma. Journal of the American College of Surgeons 2017 225, 419-427DOI: (10.1016/j.jamcollsurg.2017.05.012) Copyright © 2017 The Authors Terms and Conditions

Figure 2 Receiver operating characteristic curve analysis and identification of the optimal cutoff with the Youden index (J) for syndecan-1 as predictor of 24-hour in-hospital mortality in 410 trauma patients. Patients were defined as having the endotheliopathy of trauma (EoT+) based on a syndecan-1 level ≥40 ng/mL selected with the Youden index (J = 0.35) as the cutoff value that maximized the sum of sensitivity and specificity in predicting 24-hour in-hospital mortality. The point that corresponds to the cutoff for the upper quartile of syndecan-1 levels (≥60 ng/mL) is also represented here. AUC, area under the curve. Journal of the American College of Surgeons 2017 225, 419-427DOI: (10.1016/j.jamcollsurg.2017.05.012) Copyright © 2017 The Authors Terms and Conditions