Symptomatic efficacy of avocado–soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials R. Christensen,

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General Information Osteoarthritis and Cartilage

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Symptomatic efficacy of avocado–soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials R. Christensen, M.Sc., E.M. Bartels, D.Sc., A. Astrup, M.D., Ph.D., H. Bliddal, M.D., Ph.D. Osteoarthritis and Cartilage Volume 16, Issue 4, Pages 399-408 (April 2008) DOI: 10.1016/j.joca.2007.10.003 Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Flow of RCTs included in the systematic review. Osteoarthritis and Cartilage 2008 16, 399-408DOI: (10.1016/j.joca.2007.10.003) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Forest-plots of trials comparing ASU with placebo on pain, Lequesne, and the number of responders to treatment, respectively; size of every circle is proportional to the precision of each efficacy estimate. Osteoarthritis and Cartilage 2008 16, 399-408DOI: (10.1016/j.joca.2007.10.003) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Meta-regression relations: ESs (ESpain, ESLequesne, and ORresponders) on the vertical axis are plotted against the %hip OA patients included (A, C, and E) and trial duration (B, D, and F), respectively. Size of every circle is proportional to the precision of each efficacy estimate. The solid line indicates the predicted treatment magnitude and direction, whereas the dashed lines represent 95% CI using a REML based model. Osteoarthritis and Cartilage 2008 16, 399-408DOI: (10.1016/j.joca.2007.10.003) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Osteoarthritis and Cartilage 2008 16, 399-408DOI: (10. 1016/j. joca Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions