Volume 155, Issue 5, Pages e117-e121 (May 2019)

Slides:

Advertisements

Similar presentations

Debapriya Datta, MD, FCCP, Vanessa Yap, MD CHEST

Advertisements

Polymyositis Associated With Severe Interstitial Lung Disease

A 35-Year-Old Man With Fever, Dyspnea, and Diffuse Reticular Opacities

A Cancer That Went Up in Smoke

Volume 139, Issue 4, Pages (April 2011)

Volume 134, Issue 1, Pages (July 2008)

Volume 77, Issue 4, Pages (April 1980)

Air Pollution and Chest Disease

Britta K. Sundquist, MD, Paul G. Comber, MD, PhD, Scott H. Beegle, MD

Pulmonary Hypertension, Hemolytic Anemia, and Renal Failure

Pulmonary Hypertension and Human Immunodeficiency Virus Infection

Volume 120, Issue 3, Pages (September 2001)

Chronic Skin Eruptions Preceding a Cavitating Lung Lesion

Volume 142, Issue 3, Pages (September 2012)

A 51-Year-Old Woman With an Increasing Chest Wall Mass Years After Resection of an Early Stage Lung Cancer Ajay Dhakal, MBBS, Hongbin Chen, MD, PhD,

Megan L. Troxell, MD, PhD, Jennifer B

Volume 151, Issue 5, Pages e119-e122 (May 2017)

Volume 143, Issue 3, Pages (March 2013)

A Middle-aged Asthmatic Woman With Unresolving Cough

Megan L. Troxell, MD, PhD, Jennifer B

Metastatic pancreatic cancer masquerading as pulmonary sarcoidosis

Mohamed Ramez Mourad, MD, Olivia M. Siwoski, MD, Kyle R. Brownback, MD

Cynthia M. Magro, MD, Tracy L. Davis, MD, PhD, Drew J.B. Kurtzman, MD

Alicia K. Morgans, MD, Ran Reshef, MD, Donald E. Tsai, MD, PhD

A 67-Year-Old Man With Psoriatic Arthritis and New-Onset Dyspnea

A 61-Year-Old Caribbean Man With Thrush and Acute Respiratory Failure

Volume 113, Issue 1, Pages (January 1998)

A 26-Year-Old Man With a Pleural Effusion and Headache

Metastatic pancreatic cancer masquerading as pulmonary sarcoidosis

Debapriya Datta, MD, FCCP, Vanessa Yap, MD CHEST

Interstitial Lung Disease and Myositis in a Patient With Simultaneously Occurring Sarcoidosis and Scleroderma Henk. Groen, M.D., Dirkje S. Postma, M.D.,

Britta K. Sundquist, MD, Paul G. Comber, MD, PhD, Scott H. Beegle, MD

Chok Limsuwat, MD, Philip J. Daroca, MD, Joseph A. Lasky, MD CHEST

A 20-Year-Old Man With Fever, Chest Pain, and Lung Nodules

Volume 148, Issue 3, Pages e80-e85 (September 2015)

Volume 1, Issue 4, Pages (July 2015)

Volume 154, Issue 3, Pages e77-e81 (September 2018)

Volume 153, Issue 6, Pages e147-e152 (June 2018)

A 56-Year-Old Man With Cardiac Tamponade and Eosinophilia

A 68-Year-Old Man With Dyspnea on Exertion and Cough

Volume 154, Issue 5, Pages e147-e151 (November 2018)

A 70-Year-Old Woman With Dyspnea and Chest Pain

Volume 132, Issue 6, Pages (December 2007)

Volume 148, Issue 5, Pages e142-e147 (November 2015)

Volume 155, Issue 2, Pages e51-e54 (February 2019)

A Cancer That Went Up in Smoke

A 79-Year-Old Woman With Bilateral Cavitating Lung Nodules

An Unusual Cause of Pulmonary Nodules After Stem Cell Transplantation

A 45-Year-Old Man With Skin Lesions and Pleural Effusion

Volume 150, Issue 3, Pages e81-e85 (September 2016)

Of Lungs, Lipids, and Lollipops

An Unexpected Endobronchial Mass Appearing During Bronchoscopy

An Unusual Case of Postpartum Dyspnea

A Man in His 70s Presenting With Chest Pain and Hematuria

A 54-Year-Old Man Referred With Nonresolving Pneumonia

Trichosporon pullulans infection in 2 patients with chronic granulomatous disease: An emerging pathogen and review of the literature Edina H. Moylett,

Volume 155, Issue 3, Pages e69-e74 (March 2019)

Damian R. Compa, MD, Marc A. Judson, MD, FCCP, Scott H. Beegle, MD

Dyspnea on Exertion and Ground-Glass Infiltrates in an Ex-Smoker

Luke A. Seaburg, MD, Hiroshi Sekiguchi, MD CHEST

A 53-Year-Old Man Presenting With Diplopia and Cavitary Lung Nodules

A Diagnostic Conundrum

An Unusual Case of Postpartum Dyspnea

A Woman in Her 80s With Weakness, Hypoxia, and Bone Marrow Granulomas

Volume 155, Issue 5, Pages e141-e144 (May 2019)

Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency Paul J. Maglione, MD,

Mohamed Ramez Mourad, MD, Olivia M. Siwoski, MD, Kyle R. Brownback, MD

A 58-Year-Old Woman With Pneumonia and Gram-Negative Diplococci

A 40-Year-Old Man With Albinism and Progressive Dyspnea

A 76-Year-Old Woman With Incidental Right Middle Lobe Atelectasis

Presentation transcript:

Volume 155, Issue 5, Pages e117-e121 (May 2019) Rituximab Monotherapy for Common Variable Immune Deficiency-Associated Granulomatous-Lymphocytic Interstitial Lung Disease Julie Ng, MD, Kyle Wright, MD, PhD, Maura Alvarez, MD, Gary M. Hunninghake, MD, MPH, Duane R. Wesemann, MD, PhD CHEST Volume 155, Issue 5, Pages e117-e121 (May 2019) DOI: 10.1016/j.chest.2019.01.034 Copyright © 2019 American College of Chest Physicians Terms and Conditions

Figure 1 A and B, CT scans of the chest from a patient (case 1) with granulomatous-lymphocytic interstitial lung disease associated with common variable immunodeficiency before (A) and 1 year after (B) treatment with rituximab monotherapy. CHEST 2019 155, e117-e121DOI: (10.1016/j.chest.2019.01.034) Copyright © 2019 American College of Chest Physicians Terms and Conditions

Figure 2 A, Hematoxylin and eosin-stained sections of right middle and right lower lobes show a peribronchiolar (*) and interstitial (**) chronic inflammatory infiltrate consisting of nonnecrotizing granulomata and tertiary lymphoid structures (left). At higher magnification (right), the lymphoid structures consist of predominantly small lymphocytes with admixed larger forms and tingible-body macrophages. B, Immunohistochemical studies reveal that the follicles consist predominantly of CD20? B cells with ringing by CD3? T cells. The B cells are positive for CD10, suggestive of follicular center origin, but negative for BCL-2 within the follicular structures (F), which favors a reactive over a neoplastic process. CD21 highlights a preserved, compact underlying follicular dendritic cell meshwork. Additional special studies for fungal (methenamine silver stain), mycobacterial (acid fast), and Epstein-Barr virus infection (in situ hybridization for EBV-encoded RNA) produced negative results (data not shown). CHEST 2019 155, e117-e121DOI: (10.1016/j.chest.2019.01.034) Copyright © 2019 American College of Chest Physicians Terms and Conditions

Figure 3 A and B, CT scans of the chest from a patient (case 2) with granulomatous-lymphocytic interstitial lung disease associated with common variable immunodeficiency before (A) and 1 year after (B) starting rituximab monotherapy. CHEST 2019 155, e117-e121DOI: (10.1016/j.chest.2019.01.034) Copyright © 2019 American College of Chest Physicians Terms and Conditions