Association of opioid requirement and cancer pain with survival in advanced non-small cell lung cancer D. Zylla, M.A. Kuskowski, K. Gupta, P. Gupta

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Association of opioid requirement and cancer pain with survival in advanced non-small cell lung cancer D. Zylla, M.A. Kuskowski, K. Gupta, P. Gupta British Journal of Anaesthesia Volume 113, Pages i109-i116 (July 2014) DOI: 10.1093/bja/aeu351 Copyright © 2014 The Author(s) Terms and Conditions

Fig 1 Overall survival of patients experiencing different levels of chronic pain and requiring varying amounts of opioids (defined as described in the Methods section and Table 1) was estimated using the Kaplan–Meier method. The presence of higher levels of pain, greater opioid requirement, or both was strongly associated with shorter survival. Statistical analysis is provided in the Results section. The panels show the overall survival of patients stratified by opioid requirement and (a) severe pain during the first 90 days of chemotherapy, (b) moderate-severe pain during the first 90 days of chemotherapy, (c) severe pain during the entire clinical course (from initiation of chemotherapy to death or last follow-up), and (d) moderate-severe pain during the entire clinical course. British Journal of Anaesthesia 2014 113, i109-i116DOI: (10.1093/bja/aeu351) Copyright © 2014 The Author(s) Terms and Conditions