Marked and restricted cutaneous pigmentation induced by selective intra-arterial cisplatin infusion Teruki Yanagi, MD, Masashi Akiyama, MD, PhD, Satoru Aoyagi, MD, Akihiko Shibaki, MD, PhD, Akihiro Homma, MD, Hiroshi Shimizu, MD, PhD Journal of the American Academy of Dermatology Volume 54, Issue 2, Pages 362-363 (February 2006) DOI: 10.1016/j.jaad.2005.01.123 Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions
Fig 1 Cisplatin infusion chemotherapy induced cutaneous pigmentation restricted to the right cheek. A, Skin around the tumor before intra-arterial chemotherapy. B, Cutaneous pigmentation 10 days after the chemotherapy. Marked, dark-brown pigmentation was seen in the right cheek and the lips (arrowheads). Journal of the American Academy of Dermatology 2006 54, 362-363DOI: (10.1016/j.jaad.2005.01.123) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions
Fig 2 Skin biopsy specimen from the pigmented area on the right cheek. A, An increased number of melanocytes in the basal layer and basal melanosis were observed. B, Melanin staining clearly demonstrated the basal melanosis. C, Transmission electron microscopy demonstrated showed that melanocytes in the basal cell layer were producing a large number of melanosomes. Inset, Mature melanosomes were abundant in the cytoplasmic processes of a melanocyte. (A, Hematoxylin-eosin stain; B, Fontana-Masson stain; original magnifications: A, ×100; B, ×100; C, ×7000; inset, ×15,000.) Journal of the American Academy of Dermatology 2006 54, 362-363DOI: (10.1016/j.jaad.2005.01.123) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions