Volume 70, Issue 2, Pages (July 2006)

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Presentation transcript:

Volume 70, Issue 2, Pages 246-250 (July 2006) Discovering erythropoietin's extra-hematopoietic functions: Biology and clinical promise M. Brines, A. Cerami Kidney International Volume 70, Issue 2, Pages 246-250 (July 2006) DOI: 10.1038/sj.ki.5001546 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 Examples of gross pathology exhibiting beneficial effects of EPO or the non-erythropoietic molecule carbamylated EPO (CEPO) for tissue injury models in rodents. (a) EPO administered as a single dose (5000 U/kg-bw intraperitoneally) immediately following traumatic injury to mouse brain markedly reduces tissue loss (left) when evaluated 10 days following injury. (b) Cross-sections of the heart obtained 24 h following injury from a rat model of myocardial ischemia (30 min) with reperfusion administered carbamylated EPO (10 μg/kg-bw at reperfusion). Masson trichrome staining shows intact muscle (red) and scar (blue). (c) Carbamylated EPO (10 μg/kg-bw intravenously at reperfusion) protects rat kidney from 60 min of ischemia (renal artery occlusion) followed by reperfusion for 48 h. The vehicle-treated kidney is severely necrotic, exhibiting widespread tubular destruction (original magnification × 100). reproduced with permission from Proc Natl Acad Sci USA Kidney International 2006 70, 246-250DOI: (10.1038/sj.ki.5001546) Copyright © 2006 International Society of Nephrology Terms and Conditions