Examples of tobramycin-efflux pump hybrids: tobramycin linked to 1-(1-naphthylmethyl)-piperazine (NMP) (hybrid 14), tobramycin linked to paroxetine (hybrid.

Slides:

Advertisements

Similar presentations

Overview of potential risk or protective factors influencing the horizontal or vertical transmission of Neospora caninum and the occurrence of exogenous.

Advertisements

Itraconazole tissue and fluid concentrations in humans as multiples of the maximal or simultaneously measured concentration in plasma (μg/ml) after systemic.

Voriconazole tissue and fluid concentrations in humans as multiples of the maximal or simultaneously measured concentration in plasma (μg/ml) after systemic.

Functional range and environmental niches of the Pseudomonas genus, highlighting the broad distribution of the P. fluorescens species complex. Functional.

MIC distributions of selected β-lactam antimicrobial agents for H

Stages of pathogenesis of EAEC

Mechanisms by which microbial cells might develop resistance

Frequency of lesions detected using CNS imaging (computed tomography [CT] and magnetic resonance imaging [MRI]) on patients with baylisascariasis (see.

The human norovirus genome.

Characterization of oprD promoter elements.

Phylogenetic tree showing generic and species positions based on Bayesian analysis of the nuclear ribosomal DNA 28S region (1,200 bp) of Schistosomatidae.

RND efflux operons in P. aeruginosa.

Columbia blood agar plate showing an isogenic S

Characteristics of the new family of telomeric Cryptosporidium proteins, Cops-1 and Chos-1. Characteristics of the new family of telomeric Cryptosporidium.

Approximate numbers of cases per 100,000 individuals caused by penicillin resistance for each year (left). Approximate numbers of cases per 100,000 individuals.

MexT-associated downregulation of oprD expression.

Relative abundances of Propionibacterium species in different skin areas determined by 16S rRNA gene sequence analysis of 10 individuals. Relative abundances.

Comparative analysis of C. glabrata, C. albicans, and S

Glucose concentration-dependent increase of melanin synthesis.

Detection of Ebola virus infection in nonfatal versus fatal cases.

Evolutionary distance tree, based on 16S rDNA sequences, showing the relationship of F. tularensis with other putative members of the Francisellaceae and.

Increasing prevalence of multidrug resistance among P

Results of in vivo competition experiments in a mouse model of systemic infection (median CI values are shown by horizontal lines). Results of in vivo.

Relationships between H. pylori, inflammation, and acid secretion.

Fluconazole tissue and fluid concentrations in humans as multiples of the maximal or simultaneously measured concentration in plasma (μg/ml) after systemic.

Number of outbreaks associated with drinking water by water system type and year (n = 780), 1971 to “Other” includes outbreaks associated with bottled.

Percentages of outbreak deficiencies (n = 671) in public water systems (n = 656) by time period, 1971 to 2006, excluding outbreaks associated with Legionella.

Schematic representation of signaling by KSHV LANA

Potentiation of legacy antibiotics against P

Phylogenetic network with concatenated 16S rRNA, 23S rRNA, groEL, rpoB, and dnaK sequences (3,009 unambiguously aligned base pairs), including 71 Coxiella-like.

Examples of antibiotic hybrid drugs that are active against Gram-negative pathogens: trimethoprim linked to ciprofloxacin–BP-4Q-002 (hybrid 5), the TyrRS.

Β-Lactam hydrolysis of cephalosporin followed by nonenzymatic release of a leaving group (LG). β-Lactam hydrolysis of cephalosporin followed by nonenzymatic.

Examples of advanced hybrid antibiotics undergoing clinical trials: cadazolid (hybrid 17) and TNP-2092, also known as CBR-2092 (hybrid 18). Examples of.

Number of outbreaks associated with drinking water by system type and month (n = 762), 1971 to 2006, excluding outbreaks associated with commercially bottled.

Summary of the distribution and genetic context of the OXA-type enzymes in Acinetobacter baumannii. Summary of the distribution and genetic context of.

Percentages of 256 clinical isolates obtained from immunocompetent and immunocompromised patients (HIV positive) and from patients with other risk factors.

Fabrizio Dutly, and Martin Altwegg Clin. Microbiol. Rev. 2001; doi:10

Two different pharmacophoric domains attached covalently by a linker domain. Two different pharmacophoric domains attached covalently by a linker domain.

Shell vial system protocols used for specific isolation of Bartonella, Coxiella burnetii, rickettsiae, or T. whipplei and for unspecific research into.

Staphylococcus aureus and Staphylococcus epidermidis cell surface proteins, known as microbial surface components recognizing adhesive matrix molecules.

Structure of cefiderocol (hybrid 10), previously known as S , derived by linking ceftazidime to the siderophore catechol 2-chloro-3,4-dihydroxybenzoic.

Hector H. García et al. Clin. Microbiol. Rev. 2002; doi: /CMR

Structural classes of antimicrobial peptides.

Publications on biosensors for the field in general compared with the specific detection of whole bacteria. Publications on biosensors for the field in.

Serial testing with IGRAs reveals underlying phenotypes.

Roberta B. Carey et al. Clin. Microbiol. Rev. 2018; doi: /CMR

Various possible courses of the immune response to severe sepsis and septic shock over 28 days. Various possible courses of the immune response to severe.

Schematic representation of 5′→3′ exonuclease cleavage of a 5′-labeled (small black star) probe with a 3′-phosphate (grey circle) extension blocker. Schematic.

Synchronization of a basic diagnostic algorithm (linked diagnostic tests) with different levels of diagnostic services. Synchronization of a basic diagnostic.

Stages of biofilm development (214).

Numbers of neurotoxocariasis (NT) cases—totals and those with cerebral and myelonic involvement—analyzed among 86 clinical NT cases in the PubMed database.

Percentages of outbreak deficiencies in public water systems associated with untreated and improperly treated source water by year, 1971 to 2006, excluding.

Giemsa-stained thin blood smears from a nonobese diabetic (NOD)-SCID mouse infected with (A) B. microtistrain MN1, (B) a hamster infected with B. microti.

Number of ESBL carriers in the community in 2010, according to WHO region grouping. Number of ESBL carriers in the community in 2010, according to WHO.

The Scorpions primer is an extension of molecular beacons.

Structure and function of RND efflux pumps in P. aeruginosa.

Phylogenetic trees for fusion (F) and attachment (G) genes of selected HMPV isolates. Phylogenetic trees for fusion (F) and attachment (G) genes of selected.

Fluconazole zone diameter distributions for all Candida spp

Adherence patterns of enteropathogenic E

Relationship between MIC, dose of fluconazole, and emergence/expression of specific resistance mechanisms in oropharyngeal candidiasis. •, MIC of fluconazole.

Outcomes of infections caused by carbapenemase-producing Klebsiella pneumoniae, according to treatment regimen. Outcomes of infections caused by carbapenemase-producing.

Phylogenetic tree of the complete genomes of 27 representative human (black) and camel (red) MERS-CoV strains rooted by NeoCoV (KC ). Phylogenetic.

Cytokines and cytokine receptors involved in type I immunity in tuberculosis. Cytokines and cytokine receptors involved in type I immunity in tuberculosis.

Distribution of the four major molecular types of C

The T3SS apparatus consists of rings that provide a continuous path across the inner (IM) and outer (OM) bacterial membranes, including the peptidoglycan.

Schematic representation of the relationships between acid resistance (urease activity and urea transport), nitrogen metabolism (ammonia production), metal.

Effects of acute malnutrition on lymphoid and hematopoietic organs.

Diagrammatic view of the locations of genes encoding classical HLA class I (HLA-A, -B, -C, -E, -F, and -G) and class II (DR, DQ, DP, and DM) molecules.

Proposed United Nations “One Health” framework.

Amino acid substitutions in SHV ESBL derivatives.

Presentation transcript:

Examples of tobramycin-efflux pump hybrids: tobramycin linked to 1-(1-naphthylmethyl)-piperazine (NMP) (hybrid 14), tobramycin linked to paroxetine (hybrid 15), and tobramycin linked to the dibasic peptide (DBP) analog d-Ala–d-hPhe–aminoquinoline (MC-04,124) (hybrid 16). Examples of tobramycin-efflux pump hybrids: tobramycin linked to 1-(1-naphthylmethyl)-piperazine (NMP) (hybrid 14), tobramycin linked to paroxetine (hybrid 15), and tobramycin linked to the dibasic peptide (DBP) analog d-Ala–d-hPhe–aminoquinoline (MC-04,124) (hybrid 16). All three tobramycin-based hybrids contain a 12-carbon-long aliphatic (C12) hydrocarbon linker. Ronald Domalaon et al. Clin. Microbiol. Rev. 2018; doi:10.1128/CMR.00077-17