The Mitochondrial Pyruvate Carrier: Has It Been Unearthed at Last?

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The Mitochondrial Pyruvate Carrier: Has It Been Unearthed at Last? Andrew P. Halestrap Cell Metabolism Volume 16, Issue 2, Pages 141-143 (August 2012) DOI: 10.1016/j.cmet.2012.07.013 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Major Pathways of Mammalian Carbohydrate, Fat, and Amino Acid Metabolism that Require the MPC Pathways are color coded as indicated. The dotted green line represents the indirect pathway of oxaloacetate transport out of the mitochondria. Note that the MPC is also used for the transport of the ketone body, acetoacetate, and is known to be inhibited by phenylpyruvate and α-ketoisocaproate. These monocarboxylates accumulate in phenylketonuria and maple syrup urine disease, respectively, and may account for the perturbation of brain energy metabolism and development associated with these diseases (Halestrap et al., 1980). Cell Metabolism 2012 16, 141-143DOI: (10.1016/j.cmet.2012.07.013) Copyright © 2012 Elsevier Inc. Terms and Conditions