Severe cutaneous human papillomavirus infection associated with natural killer cell deficiency following stem cell transplantation for severe combined.

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Presentation transcript:

Severe cutaneous human papillomavirus infection associated with natural killer cell deficiency following stem cell transplantation for severe combined immunodeficiency Qurat ul Ain Kamili, MD, Filiz O. Seeborg, MD, MPH, Kapil Saxena, BA, Sarah K. Nicholas, MD, Pinaki P. Banerjee, PhD, Laura S. Angelo, PhD, Emily M. Mace, PhD, Lisa R. Forbes, MD, Caridad Martinez, MD, Teresa S. Wright, MD, Jordan S. Orange, MD, PhD, Imelda Celine Hanson, MD Journal of Allergy and Clinical Immunology Volume 134, Issue 6, Pages 1451-1453.e1 (December 2014) DOI: 10.1016/j.jaci.2014.07.009 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Multiple warts on the hands of a patient 7 years after HSCT for γc SCID (A). HPV infection in post-HSCT patients is associated with low number of NK cells in PBMCs (B). NK cell numbers were compared in patients before (left) and after (middle and right) HSCT. Failure to increase NK cell number (P < .09) after transplant is noted in patients with HPV (middle), whereas patients without HPV show higher number of NK cells (P < .0001) (right). P values were obtained by 2-tailed t test. IL-2 rescues cytotoxic effect of NK cells in HPV-positive SCID patients (C). Four-hour cytotoxicity assay was performed against K562 target cells using PBMCs from healthy donors (black) and patients with HPV (red, blue, green, and teal) in the presence (dotted line) or absence (solid line) of IL-2 (1000 U/mL); increases in IL-2-mediated cytotoxicity were significant (P < .002; 2-way ANOVA). Journal of Allergy and Clinical Immunology 2014 134, 1451-1453.e1DOI: (10.1016/j.jaci.2014.07.009) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions