Michael A. Zatina, M. D. , Christopher K. Zarins, M. D. , Bruce L

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Presentation transcript:

Role of medial lamellar architecture in the pathogenesis of aortic aneurysms Michael A. Zatina, M.D., Christopher K. Zarins, M.D., Bruce L. Gewertz, M.D., Seymour Glagov, M.D. Journal of Vascular Surgery Volume 1, Issue 3, Pages 442-448 (May 1984) DOI: 10.1016/0741-5214(84)90083-1 Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 1 Transverse section of porcine thoracic aortic media. Vessel was fixed while distended. Lamellar architecture is intact and uniform across wall. Outer media contains many vasa vasorum (V)), whereas inner wall beneath lumen (L) is avascular. (× 100.) Journal of Vascular Surgery 1984 1, 442-448DOI: (10.1016/0741-5214(84)90083-1) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 2 Higher magnification of aortic lamellae reveals that each consists of groups of smooth muscle cells (M) bracketed on each side by elastic fibers (E). Collagen bundles (C) course between successive layers. (× 400.) Journal of Vascular Surgery 1984 1, 442-448DOI: (10.1016/0741-5214(84)90083-1) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 3 Longitudinal (axial) section of porcine thoracic aortic media 2 months after ligation of vasa vasorum. There is a darkly stained necrotic zone in outer media (N). This area contains debris of necrotic smooth muscle cells with compression of persisting elastic fibers. Innermost lamellar units (I) are well preserved. (× 125.) Journal of Vascular Surgery 1984 1, 442-448DOI: (10.1016/0741-5214(84)90083-1) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 4 Longitudinal section through a site of crushing clamp injury. In spite of striking fracture-disruption of intima and many inner lamellae, aneurysmal dilatation did not occur. In this case average tangential tension per lamellar unit was 1934 dynes/cm. (× 40.) Journal of Vascular Surgery 1984 1, 442-448DOI: (10.1016/0741-5214(84)90083-1) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 5 Longitudinal section through a crushing injury site with formation of an aneurysmal dilatation. There is outward bulging of wall involving both luminal (L) and outer surfaces. In this instance average tangential tension per lamellar unit was 4803 dynes/cm. (× 62.) Journal of Vascular Surgery 1984 1, 442-448DOI: (10.1016/0741-5214(84)90083-1) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions