Chordoid Meningioma A Deceptive Nasal Mass.

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Presentation transcript:

Chordoid Meningioma A Deceptive Nasal Mass

Case Report A 32 years old male patient presented with complaint of Nasal Obstruction, Difficulty in Breathing and 4-5 episodes of epistaxis since 6 months On Anterior Rhinoscopy- A Pinkish Polypoidal mass was present in left nasal cavity

On Posterior Rhinoscopy- A Polypoidal mass from left nasal cavity was projecting in left nasopharyngeal air space On Probe Test- Mass was arising from lateral wall of nose On Diagnostic Nasal Endoscopy (DNE)- Firm pinkish polypoidal mass visualized in left nasal cavity, coming from middle meatus with no attachment on floor, roof and medial wall of nasal cavity Ear and Throat Examination- No Abnormality Detected On Indirect Laryngoscopy- No Abnormality Detected

Investigation CT Paranasal Sinus (Plain and Contrast) - An ill-defined polypoidal non-enhancing soft tissue density lesion was noted in left maxillary sinus and left ethmoidal sinus extending into the left nasal cavity involving the middle meatus causing mild deviation of nasal septum to right side. It was causing widening of ostium at medial wall of left maxillary sinus. Left nasal air space is obliterated

Biopsy- Angiomatous Polyp All Routine Blood Investigation was normal Patient was posted for Endoscopic Excision of Nasal Mass With Functional Endoscopic Sinus Surgery (FESS)

Intraoperative Endoscopic Excision of Nasal Mass along with Functional Endoscopic Sinus Surgery (FESS) was performed on patient Uncinectomy was done on left side, maxillary ostium widened and nasal polyp was removed from left maxillary sinus and left nasal cavity in toto Left Anterior Ethmoidal cells were removed Right Nasal cavity, Maxillary and Ethmoidal Sinus appear normal on endoscopy

Histopathological Examination Immunohistochemical stain for specimen- Tumour cells are positive for- Epithelial Membrane Antigen (EMA) S-100 Vimentin PR Tumour cells are negative for- CK 7 CK 20 CEA HPE of specimen shows CHORDOID MENINGIOMA

Meningothelial cells arranged in cords displaying fused cytoplasmic membranes and indistinguishable cellular borders. The nuclei look bland; however this is by definition a Grade II meningioma

Patient followed up after 7 days and 3 weeks, Diagnostic nasal endoscopic (DNE) was done on follow up MRI Brain was done after HPE diagnosis of Chordoid Meningioma, to rule out any intracranial connection of Meningioma No Intracranial and Extracranial mass visualised No growth or mass visualized on DNE Patient was asymptomatic

Discussion Meningiomas are nonglial tumors of the central nervous system, representing 24–30% of all intracranial neoplasms Chordoid Meningioma are grade II atypical meningiomas according to the WHO’s classification They have been reported to occur extracranially in only 1-2% of cases and 20% of extracranial meningiomas are secondary extensions of intracranial tumors They arise from the arachnoid cap cells (meningocytes) that are derived from the neural crest These tumors are more common in females and have bimodal age distribution with first peak at the second decade of life and second peak during fifth through seventh decades

Pathogenesis of Extra Cranial Meningioma During embryogenesis, when arachnoidal cells that are present in the sheaths of nerves or vessels emerge through the skull foramina, the displaced Pacchionian bodies are detached, pinched off or entrapped in an extracranial location They have been reported to occur in the Sino Nasal Tract, Cranial bones, Middle Ear, Scalp, Soft tissues of the face, neck and parotid gland

Symptoms depend on the anatomic site of involvement Meningioma involving Sino Nasal Tract present with- Nasal Obstruction Anosmia Facial Pain Nasal Discharge Epistaxis

Nasal Endoscopy usually shows a firm reddish pink to grey mass in the nasal cavity which could be globular or lobulated but well circumscribed with displacement and without infiltration into the surrounding tissues 

Radiological findings are usually nonspecific and include clouding or opacification of the sinuses, bony sclerosis, and focal destruction of the surrounding sinusoidal or nasal cavity bony tissues 

The differential diagnosis of Sino nasal tract meningiomas includes Mucocele, Olfactory Neuroblastoma, Carcinoma, Haemangioma, Sarcoma and Angiofibroma  Histopathology and Immunohistochemistry are confirmatory. Meningiomas are strongly immunoreactive to Vimentin, EMA (epithelial membrane antigen) and Pancytokeratin

Growth of the tumour is slow, hence surgical excision is treatment of choice Complete excision of these masses may be accomplished by Endoscopic, Open or a combination of both approaches Radiation therapy has been suggested to improve survival in meningiomas of central nervous system

Conclusion Extra cranial Meningioma is rare neoplasm, frequently misdiagnosed, resulting in inappropriate clinical management Histopathological evaluation of biopsy is must in all cases of nasal mass for accurate diagnosis and management, as significant lesions like Chordoid Meningioma may be missed on clinical and radiological evaluation

Thank You