Drugs will be different in: PHARMACOLOGY Science dealing with interactions between living systems and molecules, especially chemicals from outside the body. Drugs will be different in: Size--most small Shape--to fit receptor Chemical nature--acid/base

Drug-body interaction Pharmacodynamic: What drug does to you a) mimic or inhibit normal physiological/biochemical processes or inhibit pathological processes in animals or
(b) inhibit vital processes of endo- or ectoparasites and microbial organisms. Pharmacokinetic: What you do to drug(absorb, distribute, metabolize,eliminate)

Distribution: Depends on Blood Flow and Blood Brain Barrier

Excludes ionized substances; Active transport mechanisms; Not uniform – leaky (circumventricular areas)

Get the drug in: Oral Inhale Topical Transdermal Subcutaneous Intramuscular Buccal Sublingual Rectal Parenteral---must skip the GI tract to avoid stomach acid(some penicllins and insulin)

DRUG GROUPS Antibiotics Antifungals Antivirals Antiretrovirals Affective disorders Insomnia CNS disorders Respiratory agents Gastrointestinal agents Urinary system Cardiovascular Anticoagulant Hyperlipidemia Narcotic and opoid analgesics Non-narcotic analgesics Thyroid

DRUG GROUPS CONT Hormone replacement Bone disease Corticosteroids Hypoglycemic Topical chemotherapy

first order kinetics first order kinetics-----’halflife is 2 hrs’ 6 units in blood level at start. 3 units at 2hrs, 1.5 units at 4 hours, .75 units at 6 hours,ect zero order kinetics---starts at first order kinetics until a threshold is hit then eliminates at a constant rate