Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16- Arg/Arg patients with asthma Eric D. Bateman, MD, Oliver Kornmann,

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Presentation transcript:

Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16- Arg/Arg patients with asthma Eric D. Bateman, MD, Oliver Kornmann, MD, Peter Schmidt, PhD, Anna Pivovarova, DiplStat, Michael Engel, MD, Leonardo M. Fabbri, MD Journal of Allergy and Clinical Immunology Volume 128, Issue 2, Pages 315-322 (August 2011) DOI: 10.1016/j.jaci.2011.06.004 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Trial design. At all visits, pulse, blood pressure, and predose pulmonary function test results (determined by means of spirometry) were measured. Patients measured PEF and FEV1 each morning and evening with an electronic peak flowmeter and recorded asthma symptoms and rescue medication use in an electronic diary (5-point rating scale from 1 = no impairment to 5 = greatest impairment). Journal of Allergy and Clinical Immunology 2011 128, 315-322DOI: (10.1016/j.jaci.2011.06.004) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Screening, randomization, and study completion. Journal of Allergy and Clinical Immunology 2011 128, 315-322DOI: (10.1016/j.jaci.2011.06.004) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Mean weekly morning predose PEF (in liters per minute) during the double-blind treatment and follow-up periods. Tiotropium was noninferior to salmeterol in the primary analysis based on the change in mean weekly morning PEF from baseline to the last week of treatment (see Table II; P = .002; analysis of covariance, α = .025, 1-sided). Journal of Allergy and Clinical Immunology 2011 128, 315-322DOI: (10.1016/j.jaci.2011.06.004) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions