(A) Photomicrograph depicting typical appearance of a glomerulus in patient with mesangial type lupus nephritis, WHO class II. (Periodic acid-Schiff stain;

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(A) Photomicrograph depicting typical appearance of a glomerulus in patient with mesangial type lupus nephritis, WHO class II. (Periodic acid-Schiff stain; magnification, ×200). (A) Photomicrograph depicting typical appearance of a glomerulus in patient with mesangial type lupus nephritis, WHO class II. (Periodic acid-Schiff stain; magnification, ×200). Courtesy of Dr. Helmut Rennke. (B) Immunofluorescence micrograph of glomerulus illustrating mesangial localization of IgM in WHO class II lupus nephritis. Magnification, ×200. Courtesy of Dr. Helmut Rennke. (C) Illustration depicting a glomerulus with focal necrotizing and proliferative lesion characteristic of WHO class III focal segmental glomerulonephritis. (Silver methenamine stain; magnification, ×260). Courtesy of Dr. C. Craig Tisher. (D) Immunofluoresence micrograph of kidney biopsy from patient with class III lupus nephritis. Segmental localization of IgM is depicted in the glomerulus. Note presence of tubular membrane deposits often observed in lupus nephritis. Magnification, ×160. Courtesy of Dr. C. Craig Tisher. J. STEWART CAMERON JASN 1999;10:413-424 ©1999 by American Society of Nephrology