Kostis Gyftopoulos, M. D. , Ph. D. , Christina Chondrogianni, M. Sc

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Presentation transcript:

Increased expression of endothelin-1 and its receptors in varicocele: an immunohistochemical study Kostis Gyftopoulos, M.D., Ph.D., Christina Chondrogianni, M.Sc., Helen Papadaki, M.D., Ph.D. Fertility and Sterility Volume 95, Issue 8, Pages 2554-2556.e2 (June 2011) DOI: 10.1016/j.fertnstert.2011.04.062 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Immunohistochemical expression of combined intensity and distribution (H-score) for endothelin 1 (ET-1), ETA, and ETB in varicose (V) versus control (c) veins. (Whiskers: minimum to maximum; P<.0001, Wilcoxon signed rank test.) Fertility and Sterility 2011 95, 2554-2556.e2DOI: (10.1016/j.fertnstert.2011.04.062) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 (A) Control vein stained poorly for endothelin 1 (ET-1). (B) Increased immunostaining for ET-1 in varicose vein. Note intima and media tunica thickening. ETA immunostaining in control vein (C) and in varicose vein (D). Analogous low ETB expression in control vein (E) compared with varicose veins (F). All microphotographs, ×20. Fertility and Sterility 2011 95, 2554-2556.e2DOI: (10.1016/j.fertnstert.2011.04.062) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions