The natural history of milk allergy in an observational cohort

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The natural history of milk allergy in an observational cohort Robert A. Wood, MD, Scott H. Sicherer, MD, Brian P. Vickery, MD, Stacie M. Jones, MD, Andrew H. Liu, MD, David M. Fleischer, MD, Alice K. Henning, MS, Lloyd Mayer, MD, A. Wesley Burks, MD, Alexander Grishin, PhD, Donald Stablein, PhD, Hugh A. Sampson, MD Journal of Allergy and Clinical Immunology Volume 131, Issue 3, Pages 805-812.e4 (March 2013) DOI: 10.1016/j.jaci.2012.10.060 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Kaplan-Meier analysis of milk allergy resolution over time is shown in blue, with pointwise 95% CIs shown in red. Journal of Allergy and Clinical Immunology 2013 131, 805-812.e4DOI: (10.1016/j.jaci.2012.10.060) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Kaplan-Meier analysis representing the relationship of milk allergy resolution to baseline milk-specific IgE levels. Individual curves represent IgE levels of less than 2 kUA/L (blue), 2 to 10 kUA/L (red), and 10 kUA/L or greater (green). Journal of Allergy and Clinical Immunology 2013 131, 805-812.e4DOI: (10.1016/j.jaci.2012.10.060) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Kaplan-Meier analysis representing the relationship of milk allergy resolution to baseline milk SPT wheal size. Individual curves represent wheal sizes of less than 5 mm (blue), 5 to 10 mm (red), and greater than 10 mm (green). Journal of Allergy and Clinical Immunology 2013 131, 805-812.e4DOI: (10.1016/j.jaci.2012.10.060) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Kaplan-Meier analysis representing the relationship of milk allergy resolution to baseline AD. Individual curves represent no/mild AD (blue) and moderate/severe AD (red). Journal of Allergy and Clinical Immunology 2013 131, 805-812.e4DOI: (10.1016/j.jaci.2012.10.060) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 This figure represents results of a composite index based on the baseline milk-specific IgE level, SPT wheal, and severity of AD, which can be used to estimate the likelihood of milk allergy resolution. For example, the lower curve (red) in this figure represents a patient with a milk-specific IgE level of 20 kUA/L, an SPT mean wheal diameter of 7 mm, and moderate-to-severe AD, whereas the middle curve (green) represents a patient with the same IgE level and skin test score but no or mild AD. The upper curve (blue) represents another patient with a milk IgE level of 2 kUA/L, an SPT wheal score of 4 mm, and no or mild AD. Journal of Allergy and Clinical Immunology 2013 131, 805-812.e4DOI: (10.1016/j.jaci.2012.10.060) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Kaplan-Meier analysis representing the relationship of milk allergy resolution to baseline milk-specific IgE levels. Individual curves represent IgG4 levels of less than 0.15 mgA/mL (blue), 0.15 to 0.65 mgA/L (red), and 0.65 mgA/L or greater (green). Journal of Allergy and Clinical Immunology 2013 131, 805-812.e4DOI: (10.1016/j.jaci.2012.10.060) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions